CHEBI:90932 - cariprazine hydrochloride

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ChEBI Name cariprazine hydrochloride
ChEBI ID CHEBI:90932
Definition A hydrochloride obtained by combining cariprazine with one molar equivalent of hydrochloric acid. Used for treatment of schizophrenia and bipolar disorder.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C21H33Cl3N4O
Net Charge 0
Average Mass 463.873
Monoisotopic Mass 462.17199
InChI InChI=1S/C21H32Cl2N4O.ClH/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23;/h3-5,16-17H,6-15H2,1-2H3,(H,24,28);1H/t16-,17-;
InChIKey GPPJWWMREQHLQT-BHQIMSFRSA-N
SMILES Cl.C1[C@H](CC[C@@H](C1)CCN2CCN(CC2)C=3C(=C(C=CC3)Cl)Cl)NC(N(C)C)=O
Roles Classification
Biological Role(s): dopamine agonist
A drug that binds to and activates dopamine receptors.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Application(s): second generation antipsychotic
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
dopamine agonist
A drug that binds to and activates dopamine receptors.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
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ChEBI Ontology
Outgoing cariprazine hydrochloride (CHEBI:90932) has part cariprazine(1+) (CHEBI:90934)
cariprazine hydrochloride (CHEBI:90932) has role dopamine agonist (CHEBI:51065)
cariprazine hydrochloride (CHEBI:90932) has role second generation antipsychotic (CHEBI:65191)
cariprazine hydrochloride (CHEBI:90932) has role serotonergic antagonist (CHEBI:48279)
cariprazine hydrochloride (CHEBI:90932) is a hydrochloride (CHEBI:36807)
IUPAC Name
N'-(trans-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl)-N,N-dimethylurea hydrochloride
Synonyms Sources
cariprazine monohydrochloride ChEBI
cariprazine.HCl ChEBI
RGH-188 HCL ChemIDplus
Brand Name Source
Vraylar KEGG DRUG
Manual Xrefs Databases
Cariprazine Wikipedia
D09876 KEGG DRUG
DB06016 DrugBank
EP2251011 Patent
US2011059980 Patent
WO2009104739 Patent
View more database links
Registry Numbers Types Sources
1083076-69-0 CAS Registry Number KEGG DRUG
1083076-69-0 CAS Registry Number ChemIDplus
18784660 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
26510944 PubMed citation Europe PMC
26535019 PubMed citation Europe PMC
Last Modified
13 January 2016