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loperamide (CHEBI:6532)

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ChEBI Name loperamide
ChEBI ID CHEBI:6532
Definition A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula Source
C29H33ClN2O2 KEGG COMPOUND
Net Charge 0
Average Mass 477.03800
InChI
InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
InChIKey
RDOIQAHITMMDAJ-UHFFFAOYSA-N
SMILES
CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1
Roles Classification
Biological Role(s): mu-opioid receptor agonist
A compound that exhibits agonist activity at the mu-opioid receptor.
Application(s): mu-opioid receptor agonist
A compound that exhibits agonist activity at the mu-opioid receptor.
antidiarrhoeal drug
Any drug found useful in the symptomatic treatment of diarrhoea.
View more on the ChEBI Ontology
ChEBI Ontology
Outgoing loperamide (CHEBI:6532) has role μ-opioid receptor agonist (CHEBI:55322)
loperamide (CHEBI:6532) has role antidiarrhoeal drug (CHEBI:55323)
loperamide (CHEBI:6532) is a monocarboxylic acid amide (CHEBI:29347)
loperamide (CHEBI:6532) is a organochlorine compound (CHEBI:36683)
loperamide (CHEBI:6532) is a piperidines (CHEBI:26151)
IUPAC Name
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
INNs Sources
loperamida ChemIDplus
loperamide ChemIDplus
loperamidum ChemIDplus
Synonym Source
Loperamide KEGG COMPOUND
Database Links Databases
C07080 KEGG COMPOUND
D08144 KEGG DRUG
DB00836 DrugBank
FR2100711 Patent
HMDB04999 HMDB
Loperamide Wikipedia
US3714159 Patent
View more database links
Registry Numbers Types Sources
1558273 Reaxys Registry Number Reaxys
1558273 Beilstein Registry Number Beilstein
53179-11-6 CAS Registry Number KEGG COMPOUND
53179-11-6 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
15900907 PubMed citation CiteXplore
19034106 PubMed citation CiteXplore
24398461 PubMed citation CiteXplore
Last Modified
28 July 2014

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