tenocyclidine (CHEBI:64610)

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ChEBI Name	tenocyclidine

ChEBI ID	CHEBI:64610

Definition	A tertiary amino compound that consists of cyclohexane having piperidin-1-yl and thiophen-2-yl groups attached at position 1. A dissociative anaesthetic drug with halluccinogenic and stimulant effects. Its effects are similar to those of phencyclidine (PCP, an analogue with the thienyl group replaced by phenyl), but it is rather more potent.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C15H23NS

Net Charge

Average Mass

249.41500

Monoisotopic Mass

249.15512

InChI

InChI=1S/C15H23NS/c1-3-9-15(10-4-1,14-8-7-13-17-14)16-11-5-2-6-12-16/h7-8,13H,1-6,9-12H2

InChIKey

JUZZEWSCNBCFRL-UHFFFAOYSA-N

SMILES

C1CCN(CC1)C1(CCCCC1)c1cccs1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	NMDA receptor antagonist Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.

Application(s):	central nervous system stimulant Any drug that enhances the activity of the central nervous system. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. hallucinogen Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations and other alterations of mood and thinking.

ChEBI Ontology
Outgoing	tenocyclidine (CHEBI:64610) has role central nervous system stimulant (CHEBI:35337) tenocyclidine (CHEBI:64610) has role hallucinogen (CHEBI:35499) tenocyclidine (CHEBI:64610) has role neuroprotective agent (CHEBI:63726) tenocyclidine (CHEBI:64610) has role NMDA receptor antagonist (CHEBI:60643) tenocyclidine (CHEBI:64610) is a piperidines (CHEBI:26151) tenocyclidine (CHEBI:64610) is a tertiary amino compound (CHEBI:50996) tenocyclidine (CHEBI:64610) is a thiophenes (CHEBI:26961)

IUPAC Name

1-[1-(2-thienyl)cyclohexyl]piperidine

Synonyms	Sources
1-[1-(thiophen-2-yl)cyclohexyl]piperidine	ChEBI
thienyl cyclohexylpiperidine	DrugBank

Last Modified

21 August 2012