A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
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This entity has been manually annotated by the ChEBI Team.
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
2-methyl-6-(phenylethynyl)pyridine
(CHEBI:64159)
has parent hydride
acetylene
(CHEBI:27518)
2-methyl-6-(phenylethynyl)pyridine
(CHEBI:64159)
has role
anxiolytic drug
(CHEBI:35474)
2-methyl-6-(phenylethynyl)pyridine
(CHEBI:64159)
has role
metabotropic glutamate receptor antagonist
(CHEBI:63963)
2-methyl-6-(phenylethynyl)pyridine
(CHEBI:64159)
is a
acetylenic compound
(CHEBI:73474)
2-methyl-6-(phenylethynyl)pyridine
(CHEBI:64159)
is a
methylpyridines
(CHEBI:25340)
2-methyl-6-(phenylethynyl)pyridine
(CHEBI:64159)
is conjugate base of
2-methyl-6-(phenylethynyl)pyridinium(1+)
(CHEBI:64160)
Incoming
2-methyl-6-(phenylethynyl)pyridinium(1+)
(CHEBI:64160)
is conjugate acid of
2-methyl-6-(phenylethynyl)pyridine
(CHEBI:64159)