CHEBI:63613 - nevirapine

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name nevirapine
ChEBI ID CHEBI:63613
Definition A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Anonymous
Secondary ChEBI IDs CHEBI:7546
Supplier Information
Save molfile Download Molfile
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C15H14N4O
Net Charge 0
Average Mass 266.29790
InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChIKey NQDJXKOVJZTUJA-UHFFFAOYSA-N
SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12
Roles Classification
Biological Role(s): antiviral drug
A substance used in the prophylaxis or therapy of virus diseases.
HIV-1 reverse transcriptase inhibitor
An entity which inhibits the activity of HIV-1 reverse transcriptase.
Application(s): antiviral drug
A substance used in the prophylaxis or therapy of virus diseases.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing nevirapine (CHEBI:63613) has role antiviral drug (CHEBI:36044)
nevirapine (CHEBI:63613) has role HIV-1 reverse transcriptase inhibitor (CHEBI:53756)
nevirapine (CHEBI:63613) is a dipyridodiazepine (CHEBI:63667)
IUPAC Name
11-cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
INN Source
nevirapine ChemIDplus
Synonyms Sources
11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one ChemIDplus
NEV DrugBank
Nevirapine KEGG COMPOUND
NVP DrugBank
Brand Name Source
Viramune KEGG DRUG
Database Links Databases
C07263 KEGG COMPOUND
D00435 KEGG DRUG
DB00238 DrugBank
LSM-5336 LINCS
Nevirapine Wikipedia
NVP PDBeChem
View more database links
Registry Numbers Types Sources
129618-40-2 CAS Registry Number KEGG COMPOUND
129618-40-2 CAS Registry Number ChemIDplus
4757598 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
1712395 PubMed citation CiteXplore
25017682 PubMed citation CiteXplore
Last Modified
25 February 2016