haloperidol (CHEBI:5613)

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ChEBI Name	haloperidol

ChEBI ID	CHEBI:5613

Definition	A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C21H23ClFNO2

Net Charge

Average Mass

375.86400

Monoisotopic Mass

375.14013

InChI

InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

InChIKey

LNEPOXFFQSENCJ-UHFFFAOYSA-N

SMILES

OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1

Roles Classification
Biological Role(s):	dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

Application(s):	dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. antidyskinesia agent Any compound which can be used to treat or alleviate the symptoms of dyskinesia. antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. first generation antipsychotic Antipsychotic drugs which can have different modes of action but which tend to be more likely than second generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements; such body movements can become permanent even after treatment has ceased. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

ChEBI Ontology
Outgoing	haloperidol (CHEBI:5613) has role antidyskinesia agent (CHEBI:66956) haloperidol (CHEBI:5613) has role antiemetic (CHEBI:50919) haloperidol (CHEBI:5613) has role dopaminergic antagonist (CHEBI:48561) haloperidol (CHEBI:5613) has role first generation antipsychotic (CHEBI:65190) haloperidol (CHEBI:5613) has role serotonergic antagonist (CHEBI:48279) haloperidol (CHEBI:5613) is a aromatic ketone (CHEBI:76224) haloperidol (CHEBI:5613) is a hydroxypiperidine (CHEBI:48590) haloperidol (CHEBI:5613) is a monochlorobenzenes (CHEBI:83403) haloperidol (CHEBI:5613) is a organofluorine compound (CHEBI:37143) haloperidol (CHEBI:5613) is a tertiary alcohol (CHEBI:26878)

IUPAC Name

4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one

Synonyms	Sources
1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine	ChemIDplus
4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone	NIST Chemistry WebBook
4'-fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone	NIST Chemistry WebBook
4-(4-(para-chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone	NIST Chemistry WebBook
4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one	IUPHAR
γ-(4-(p-chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone	NIST Chemistry WebBook

Brand Name	Source
Haldol	KEGG DRUG

Last Modified

22 February 2017