CHEBI:3398 - carbinoxamine

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ChEBI Name carbinoxamine
ChEBI ID CHEBI:3398
Definition An organochlorine compound that is 2-(4-chlorobenzyl)pyridine in which one of the benzylic hydrogens is substituted by 2-(dimethylamino)ethoxy group. It is an ethanolamine-type antihistamine, used as its maleate salt for treating hay fever, as well as mild cases of Parkinson's disease.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:166273
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Formula C16H19ClN2O
Net Charge 0
Average Mass 290.78800
InChI InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3
InChIKey OJFSXZCBGQGRNV-UHFFFAOYSA-N
SMILES CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1
Roles Classification
Biological Role(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
Application(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
anti-allergic agent
A drug used to treat allergic reactions.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
antiparkinson drug
A drug used in the treatment of Parkinson's disease.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing carbinoxamine (CHEBI:3398) has role anti-allergic agent (CHEBI:50857)
carbinoxamine (CHEBI:3398) has role antiparkinson drug (CHEBI:48407)
carbinoxamine (CHEBI:3398) has role H1-receptor antagonist (CHEBI:37955)
carbinoxamine (CHEBI:3398) has role muscarinic antagonist (CHEBI:48876)
carbinoxamine (CHEBI:3398) is a monochlorobenzenes (CHEBI:83403)
carbinoxamine (CHEBI:3398) is a pyridines (CHEBI:26421)
carbinoxamine (CHEBI:3398) is a tertiary amino compound (CHEBI:50996)
Incoming carbinoxamine maleate (CHEBI:31353) has part carbinoxamine (CHEBI:3398)
(R)-carbinoxamine (CHEBI:59328) is a carbinoxamine (CHEBI:3398)
(S)-carbinoxamine (CHEBI:59329) is a carbinoxamine (CHEBI:3398)
IUPAC Name
2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine
INNs Sources
carbinoxamina ChemIDplus
carbinoxamine ChemIDplus
carbinoxamine WHO MedNet
carbinoxaminum ChemIDplus
Synonyms Sources
(±)-carbinoxamine ChemIDplus
2-(p-chloro-α-(2-(dimethylamino)ethoxy)benzyl)pyridine ChemIDplus
Carbinoxamine KEGG COMPOUND
carbinoxamine base NIST Chemistry WebBook
paracarbinoxamine ChemIDplus
{2-[(4-Chloro-phenyl)-pyridin-2-yl-methoxy]-ethyl}-dimethyl-amine ChEMBL
Database Links Databases
C06871 KEGG COMPOUND
Carbinoxamine Wikipedia
D07617 KEGG DRUG
DB00748 DrugBank
HMDB14886 HMDB
US2606195 Patent
US2800485 Patent
View more database links
Registry Numbers Types Sources
250475 Reaxys Registry Number Reaxys
250475 Beilstein Registry Number Beilstein
486-16-8 CAS Registry Number NIST Chemistry WebBook
486-16-8 CAS Registry Number ChemIDplus
Citation Waiting for Citations Type Source
6094812 PubMed citation ChEMBL
Last Modified
23 October 2014