CHEBI:3387 - carbamazepine

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ChEBI Name carbamazepine
ChEBI ID CHEBI:3387
Definition A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:115086
Supplier Information
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Formula C15H12N2O
Net Charge 0
Average Mass 236.26860
Monoisotopic Mass 236.095
InChI InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
InChIKey FFGPTBGBLSHEPO-UHFFFAOYSA-N
SMILES NC(=O)N1c2ccccc2C=Cc2ccccc12
Roles Classification
Chemical Role(s): environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
Biological Role(s): drug allergen
Any drug which causes the onset of an allergic reaction.
sodium channel blocker
An agent that inhibits sodium influx through cell membranes.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
EC 3.5.1.98 (histone deacetylase) inhibitor
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
mitogen
A chemical substance that encourages a cell to commence cell division, triggering mitosis.
glutamate transporter activator
A neurotransmitter transporter modulator that activates glutamate transporters.
Application(s): drug allergen
Any drug which causes the onset of an allergic reaction.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
antimanic drug
Antimanic drugs are agents used to treat bipolar disorders or mania associated with other affective disorders.
anticonvulsant
A drug used to prevent seizures or reduce their severity.
glutamate transporter activator
A neurotransmitter transporter modulator that activates glutamate transporters.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing carbamazepine (CHEBI:3387) has role analgesic (CHEBI:35480)
carbamazepine (CHEBI:3387) has role anticonvulsant (CHEBI:35623)
carbamazepine (CHEBI:3387) has role antimanic drug (CHEBI:35477)
carbamazepine (CHEBI:3387) has role drug allergen (CHEBI:88188)
carbamazepine (CHEBI:3387) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
carbamazepine (CHEBI:3387) has role environmental contaminant (CHEBI:78298)
carbamazepine (CHEBI:3387) has role glutamate transporter activator (CHEBI:64370)
carbamazepine (CHEBI:3387) has role mitogen (CHEBI:52290)
carbamazepine (CHEBI:3387) has role non-narcotic analgesic (CHEBI:35481)
carbamazepine (CHEBI:3387) has role sodium channel blocker (CHEBI:38633)
carbamazepine (CHEBI:3387) has role xenobiotic (CHEBI:35703)
carbamazepine (CHEBI:3387) is a dibenzoazepine (CHEBI:47804)
carbamazepine (CHEBI:3387) is a ureas (CHEBI:47857)
Incoming carbamazepine-10,11-epoxide (CHEBI:3388) has functional parent carbamazepine (CHEBI:3387)
licarbazepine (CHEBI:701) has functional parent carbamazepine (CHEBI:3387)
IUPAC Name
5H-dibenzo[b,f]azepine-5-carboxamide
INNs Sources
carbamazepina ChemIDplus
carbamazepine ChemIDplus
carbamazepinum ChemIDplus
Synonyms Sources
5-Carbamoyl-5H-dibenz(b,f)azepine ChemIDplus
5-carbamoyl-5H-dibenz[b,f]azepine NIST Chemistry WebBook
5-Carbamoyl-5H-dibenzo(b,f)azepine ChemIDplus
5-Carbamyl-5H-dibenzo(b,f)azepine ChemIDplus
5H-Dibenz(b,f)azepine-5-carboxamide ChemIDplus
Carbamazepen ChemIDplus
Brand Name Source
Carnexiv ChemIDplus
Database Links Databases
489 DrugCentral
C06868 KEGG COMPOUND
Carbamazepine Wikipedia
D00252 KEGG DRUG
DB00564 DrugBank
HMDB0014704 HMDB
LSM-3610 LINCS
US2004220187 Patent
US2007167446 Patent
US2011177136 Patent
US2011245283 Patent
US2948718 Patent
View more database links
Registry Numbers Types Sources
1246090 Beilstein Registry Number Beilstein
1246090 Reaxys Registry Number Reaxys
298-46-4 CAS Registry Number NIST Chemistry WebBook
298-46-4 CAS Registry Number ChemIDplus
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Last Modified
22 February 2017
General Comment
2014-10-29 Stravs M, Schymanski E, Singer H, Department of Environmental Chemistry, Eawag