CHEBI:31413 - clobazam

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ChEBI Name clobazam
ChEBI ID CHEBI:31413
Definition 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:211390
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Formula C16H13ClN2O2
Net Charge 0
Average Mass 300.74000
Monoisotopic Mass 300.067
InChI InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
InChIKey CXOXHMZGEKVPMT-UHFFFAOYSA-N
SMILES CN1C(=O)CC(=O)N(c2ccccc2)c2cc(Cl)ccc12
Roles Classification
Biological Role(s): GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
Application(s): anticonvulsant
A drug used to prevent seizures or reduce their severity.
anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing clobazam (CHEBI:31413) has role anticonvulsant (CHEBI:35623)
clobazam (CHEBI:31413) has role anxiolytic drug (CHEBI:35474)
clobazam (CHEBI:31413) has role GABA modulator (CHEBI:50268)
clobazam (CHEBI:31413) is a 1,4-benzodiazepinone (CHEBI:35500)
clobazam (CHEBI:31413) is a organochlorine compound (CHEBI:36683)
IUPAC Name
7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
INNs Sources
clobazam ChemIDplus
clobazamum ChemIDplus
Synonyms Sources
1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine ChemIDplus
7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione ChEMBL
CLOBAZAM ChEMBL
Database Links Databases
682 DrugCentral
BE707667 Patent
Clobazam Wikipedia
D01253 KEGG DRUG
DB00349 DrugBank
HMDB0014493 HMDB
US3984398 Patent
View more database links
Registry Numbers Types Sources
22316-47-8 CAS Registry Number KEGG DRUG
22316-47-8 CAS Registry Number NIST Chemistry WebBook
22316-47-8 CAS Registry Number ChemIDplus
758410 Beilstein Registry Number Beilstein
758410 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017