CHEBI:3112 - biperiden

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ChEBI Name biperiden
ChEBI ID CHEBI:3112
Definition A member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:251063
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Formula C21H29NO
Net Charge 0
Average Mass 311.46110
Monoisotopic Mass 311.225
InChI InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2
InChIKey YSXKPIUOCJLQIE-UHFFFAOYSA-N
SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1
Roles Classification
Biological Role(s): muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
parasympatholytic
Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists.
Application(s): antidote to sarin poisoning
A role borne by a molecule that acts to counteract or neutralise the nerve agent sarin.
antidyskinesia agent
Any compound which can be used to treat or alleviate the symptoms of dyskinesia.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
parasympatholytic
Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists.
antiparkinson drug
A drug used in the treatment of Parkinson's disease.
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ChEBI Ontology
Outgoing biperiden (CHEBI:3112) has role antidote to sarin poisoning (CHEBI:136860)
biperiden (CHEBI:3112) has role antidyskinesia agent (CHEBI:66956)
biperiden (CHEBI:3112) has role antiparkinson drug (CHEBI:48407)
biperiden (CHEBI:3112) has role muscarinic antagonist (CHEBI:48876)
biperiden (CHEBI:3112) has role parasympatholytic (CHEBI:50370)
biperiden (CHEBI:3112) is a piperidines (CHEBI:26151)
biperiden (CHEBI:3112) is a tertiary alcohol (CHEBI:26878)
biperiden (CHEBI:3112) is a tertiary amino compound (CHEBI:50996)
Incoming biperiden hydrochloride (CHEBI:59171) has part biperiden (CHEBI:3112)
IUPAC Name
1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol
INNs Sources
biperiden ChemIDplus
biperidene ChemIDplus
biperideno ChemIDplus
biperidenum ChemIDplus
Synonyms Sources
1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol ChEMBL
α-5-norbornen-2-yl-α-phenyl-1-piperidinepropanol ChEBI
α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-1-piperidinepropanol ChEBI
Database Links Databases
374 DrugCentral
Biperiden Wikipedia
C07941 KEGG COMPOUND
D00779 KEGG DRUG
DB00810 DrugBank
LSM-1235 LINCS
US2789110 Patent
View more database links
Registry Numbers Types Sources
290038 Beilstein Registry Number Beilstein
514-65-8 CAS Registry Number ChemIDplus
514-65-8 CAS Registry Number NIST Chemistry WebBook
Citations Waiting for Citations Types Sources
10877003 PubMed citation Europe PMC
12873507 PubMed citation ChEMBL
25160769 PubMed citation Europe PMC
25466702 PubMed citation Europe PMC
2579237 PubMed citation ChEMBL
26479221 PubMed citation Europe PMC
28216067 PubMed citation Europe PMC
Last Modified
20 April 2017