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CHEBI:17026 - progesterone

ChEBI IDCHEBI:17026
ChEBI Nameprogesterone
Stars
DefinitionA C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Secondary ChEBI IDsCHEBI:439, CHEBI:8453, CHEBI:14896, CHEBI:18798, CHEBI:26269, CHEBI:28589, CHEBI:45786
Last Modified22 February 2017
DownloadsMolfile
FormulaC21H30O2
Net Charge0
Average Mass314.469
Monoisotopic Mass314.22458
SMILES[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(C)=O)CC[C@@]21[H]
InChIInChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChIKeyRJKFOVLPORLFTN-LEKSSAKUSA-N
Wikipedia
Species of MetaboliteComponentSourceComments
Homo sapiens (ncbitaxon:9606) - DOI (10.1038/nbt.2488)
Mus musculus (ncbitaxon:10090) - PubMed (19425150) Source: BioModels - MODEL1507180067
Roles Classification
Biological Roles:
mouse metabolite  Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
progesterone receptor agonist  A hormone agonist that binds to and activates progesterone receptors.
progestin  A synthetic progestogen.
human metabolite  Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
hormone  Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
Applications:
contraceptive drug  A chemical substance that prevents or reduces the probability of conception.
progesterone receptor agonist  A hormone agonist that binds to and activates progesterone receptors.
ChEBI Ontology
Outgoing Relation(s)
progesterone (CHEBI:17026) has parent hydride pregnane (CHEBI:8386)
progesterone (CHEBI:17026) has role contraceptive drug (CHEBI:49323)
progesterone (CHEBI:17026) has role human metabolite (CHEBI:77746)
progesterone (CHEBI:17026) has role mouse metabolite (CHEBI:75771)
progesterone (CHEBI:17026) has role progesterone receptor agonist (CHEBI:70709)
progesterone (CHEBI:17026) has role progestin (CHEBI:59826)
progesterone (CHEBI:17026) is a 20-oxo steroid (CHEBI:36885)
progesterone (CHEBI:17026) is a 3-oxo-Δ4 steroid (CHEBI:47909)
progesterone (CHEBI:17026) is a C21-steroid hormone (CHEBI:64600)
Incoming Relation(s)
11-deoxycorticosterone (CHEBI:16973) has functional parent progesterone (CHEBI:17026)
11,21-dioxoprogesterone (CHEBI:78601) has functional parent progesterone (CHEBI:17026)
11α-hydroxyprogesterone (CHEBI:16076) has functional parent progesterone (CHEBI:17026)
11β-hydroxyprogesterone (CHEBI:28247) has functional parent progesterone (CHEBI:17026)
12α-hydroxyprogesterone (CHEBI:34153) has functional parent progesterone (CHEBI:17026)
15β-hydroxyprogesterone (CHEBI:59418) has functional parent progesterone (CHEBI:17026)
16,17-didehydroprogesterone (CHEBI:18204) has functional parent progesterone (CHEBI:17026)
16α-hydroxyprogesterone (CHEBI:15826) has functional parent progesterone (CHEBI:17026)
16β-methylpregn-4-ene-3,20-dione (CHEBI:79767) has functional parent progesterone (CHEBI:17026)
17α-hydroxyprogesterone (CHEBI:17252) has functional parent progesterone (CHEBI:17026)
2,5-dioxo-1-pyrrolidinyl 6-(6-{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl}amino)hexanoate (CHEBI:62026) has functional parent progesterone (CHEBI:17026)
21-dehydrocortisol (CHEBI:78595) has functional parent progesterone (CHEBI:17026)
21-dehydrocortisone (CHEBI:78596) has functional parent progesterone (CHEBI:17026)
3-(progesterone-4-yl)thiopropionic acid (CHEBI:62022) has functional parent progesterone (CHEBI:17026)
3-(progesterone-7α-yl)thiopropionic acid (CHEBI:62023) has functional parent progesterone (CHEBI:17026)
4-pregnen-3β-ol-20-one (CHEBI:85899) has functional parent progesterone (CHEBI:17026)
4-pregnen-3β,20α-diol (CHEBI:85903) has functional parent progesterone (CHEBI:17026)
5α-pregnane-3,20-dione (CHEBI:28952) has functional parent progesterone (CHEBI:17026)
6-(6-{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl}amino)hexanoic acid (CHEBI:62025) has functional parent progesterone (CHEBI:17026)
6-{3-[(progesterone-4-yl)thiopropionyl]amino}hexanoic acid (CHEBI:62024) has functional parent progesterone (CHEBI:17026)
6β,16α,17α-trihydroxyprogesterone (CHEBI:137046) has functional parent progesterone (CHEBI:17026)
9-fluoro-2α-methylpregn-4-ene-3,11,20-trione (CHEBI:79773) has functional parent progesterone (CHEBI:17026)
progesterone 3-O-(carboxymethyl)oxime (CHEBI:62042) has functional parent progesterone (CHEBI:17026)
Δ1-progesterone (CHEBI:34073) has functional parent progesterone (CHEBI:17026)
IUPAC Name 
pregn-4-ene-3,20-dione
Synonyms  Source
(S)-Pregn-4-en-3,20-dioneKEGG COMPOUND
(S)-ProgesteroneKEGG COMPOUND
(S)-4-Pregnene-3,20-dioneKEGG COMPOUND
ProgesteroneKEGG COMPOUND
4-Pregnene-3,20-dioneKEGG COMPOUND
PROGESTERONEPDBeChem
UniProt Name  Source
progesteroneUniProt
Manual XrefsDatabases
C00410KEGG COMPOUND
C00410KEGG COMPOUND
STRPDBeChem
D00066KEGG DRUG
DB00396DrugBank
ProgesteroneWikipedia
HMDB0001830HMDB
PROGESTERONEMetaCyc
2279DrugCentral
Registry NumbersSources
Gmelin:708590Gmelin
Reaxys:1915950Reaxys
CAS:57-83-0KEGG COMPOUND
CAS:57-83-0ChemIDplus
CAS:57-83-0NIST Chemistry WebBook
Citations