CHEBI:17026 - progesterone

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ChEBI Name progesterone
ChEBI ID CHEBI:17026
Definition A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:18798, CHEBI:45786, CHEBI:14896, CHEBI:26269, CHEBI:439, CHEBI:8453, CHEBI:28589
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Formula C21H30O2
Net Charge 0
Average Mass 314.46170
Monoisotopic Mass 314.225
InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChIKey RJKFOVLPORLFTN-LEKSSAKUSA-N
SMILES [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])C(C)=O
Metabolite of Species Details
Mus musculus (NCBI:10090) Source: BioModels - MODEL1507180067 See: PubMed
Homo sapiens (NCBI:9606) See: DOI
Roles Classification
Biological Role(s): progestin
A synthetic progestogen.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
progesterone receptor agonist
A hormone agonist that binds to and activates progesterone receptors.
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
(via steroid hormone )
Application(s): contraceptive drug
A chemical substance that prevents or reduces the probability of conception.
progesterone receptor agonist
A hormone agonist that binds to and activates progesterone receptors.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing progesterone (CHEBI:17026) has parent hydride pregnane (CHEBI:8386)
progesterone (CHEBI:17026) has role contraceptive drug (CHEBI:49323)
progesterone (CHEBI:17026) has role human metabolite (CHEBI:77746)
progesterone (CHEBI:17026) has role mouse metabolite (CHEBI:75771)
progesterone (CHEBI:17026) has role progesterone receptor agonist (CHEBI:70709)
progesterone (CHEBI:17026) has role progestin (CHEBI:59826)
progesterone (CHEBI:17026) is a 20-oxo steroid (CHEBI:36885)
progesterone (CHEBI:17026) is a 3-oxo-Δ4 steroid (CHEBI:47909)
progesterone (CHEBI:17026) is a C21-steroid hormone (CHEBI:64600)
Incoming Δ1-progesterone (CHEBI:34073) has functional parent progesterone (CHEBI:17026)
11α-hydroxyprogesterone (CHEBI:16076) has functional parent progesterone (CHEBI:17026)
11β-hydroxyprogesterone (CHEBI:28247) has functional parent progesterone (CHEBI:17026)
11,21-dioxoprogesterone (CHEBI:78601) has functional parent progesterone (CHEBI:17026)
11-deoxycorticosterone (CHEBI:16973) has functional parent progesterone (CHEBI:17026)
12α-hydroxyprogesterone (CHEBI:34153) has functional parent progesterone (CHEBI:17026)
15β-hydroxyprogesterone (CHEBI:59418) has functional parent progesterone (CHEBI:17026)
16α-hydroxyprogesterone (CHEBI:15826) has functional parent progesterone (CHEBI:17026)
16β-methylpregn-4-ene-3,20-dione (CHEBI:79767) has functional parent progesterone (CHEBI:17026)
16,17-didehydroprogesterone (CHEBI:18204) has functional parent progesterone (CHEBI:17026)
17α-hydroxyprogesterone (CHEBI:17252) has functional parent progesterone (CHEBI:17026)
2,5-dioxo-1-pyrrolidinyl 6-(6-{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl}amino)hexanoate (CHEBI:62026) has functional parent progesterone (CHEBI:17026)
21-dehydrocortisol (CHEBI:78595) has functional parent progesterone (CHEBI:17026)
21-dehydrocortisone (CHEBI:78596) has functional parent progesterone (CHEBI:17026)
3-(progesterone-4-yl)thiopropionic acid (CHEBI:62022) has functional parent progesterone (CHEBI:17026)
3-(progesterone-7α-yl)thiopropionic acid (CHEBI:62023) has functional parent progesterone (CHEBI:17026)
4-pregnen-3β,20α-diol (CHEBI:85903) has functional parent progesterone (CHEBI:17026)
4-pregnen-3β-ol-20-one (CHEBI:85899) has functional parent progesterone (CHEBI:17026)
5α-pregnane-3,20-dione (CHEBI:28952) has functional parent progesterone (CHEBI:17026)
6β,16α,17α-trihydroxyprogesterone (CHEBI:137046) has functional parent progesterone (CHEBI:17026)
6-(6-{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl}amino)hexanoic acid (CHEBI:62025) has functional parent progesterone (CHEBI:17026)
6-{3-[(progesterone-4-yl)thiopropionyl]amino}hexanoic acid (CHEBI:62024) has functional parent progesterone (CHEBI:17026)
9-fluoro-2α-methylpregn-4-ene-3,11,20-trione (CHEBI:79773) has functional parent progesterone (CHEBI:17026)
progesterone 3-O-(carboxymethyl)oxime (CHEBI:62042) has functional parent progesterone (CHEBI:17026)
IUPAC Name
pregn-4-ene-3,20-dione
Synonyms Sources
(S)-4-Pregnene-3,20-dione KEGG COMPOUND
(S)-Pregn-4-en-3,20-dione KEGG COMPOUND
(S)-Progesterone KEGG COMPOUND
17α-progesterone NIST Chemistry WebBook
4-Pregnene-3,20-dione KEGG COMPOUND
Agolutin NIST Chemistry WebBook
Akrolutin ChEBI
corpus luteum hormone ChemIDplus
Crinone ChemIDplus
Δ4-pregnene-3,20-dione ChEBI
Gelbkörperhormon ChEBI
luteohormone ChemIDplus
Progesteron ChEBI
Progesterone KEGG COMPOUND
PROGESTERONE PDBeChem
progesterone UniProt
Database Links Databases
2279 DrugCentral
C00410 KEGG COMPOUND
D00066 KEGG DRUG
DB00396 DrugBank
HMDB0001830 HMDB
Progesterone Wikipedia
PROGESTERONE MetaCyc
STR PDBeChem
View more database links
Registry Numbers Types Sources
1915950 Reaxys Registry Number Reaxys
1915950 Beilstein Registry Number Beilstein
57-83-0 CAS Registry Number KEGG COMPOUND
57-83-0 CAS Registry Number NIST Chemistry WebBook
57-83-0 CAS Registry Number ChemIDplus
708590 Gmelin Registry Number Gmelin
Citations Waiting for Citations Types Sources
10438974 PubMed citation Europe PMC
9506942 PubMed citation Europe PMC
Last Modified
22 February 2017