CHEBI:133824 - GNF6702

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ChEBI Name GNF6702
ChEBI ID CHEBI:133824
Definition An aromatic amide obtained by formal condensation of the carboxy group of 2,4-dimethyl-1,3-oxazole-5-carboxylic acid with the aromatic amino group of 4-fluoro-3-[6-(pyridin-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]aniline. A proteasome inhibitor known to be active against the three parasites that cause Chagas disease, leishmaniasis and sleeping sickness.
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Formula C22H16FN7O2
Net Charge 0
Average Mass 429.407
Monoisotopic Mass 429.135
InChI InChI=1S/C22H16FN7O2/c1-12-19(32-13(2)26-12)21(31)27-15-6-7-17(23)16(9-15)20-28-22-25-10-14(11-30(22)29-20)18-5-3-4-8-24-18/h3-11H,1-2H3,(H,27,31)
InChIKey WXZFCGRYVWYYTG-UHFFFAOYSA-N
SMILES C1(=CN2N=C(N=C2N=C1)C=3C=C(C=CC3F)NC(=O)C=4OC(=NC4C)C)C=5N=CC=CC5
Roles Classification
Biological Role(s): antileishmanial agent
An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.
Application(s): proteasome inhibitor
A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
antileishmanial agent
An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.
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ChEBI Ontology
Outgoing GNF6702 (CHEBI:133824) has role antileishmanial agent (CHEBI:70868)
GNF6702 (CHEBI:133824) has role proteasome inhibitor (CHEBI:52726)
GNF6702 (CHEBI:133824) is a 1,3-oxazoles (CHEBI:46812)
GNF6702 (CHEBI:133824) is a aromatic amide (CHEBI:62733)
GNF6702 (CHEBI:133824) is a monofluorobenzenes (CHEBI:83575)
GNF6702 (CHEBI:133824) is a pyridines (CHEBI:26421)
GNF6702 (CHEBI:133824) is a ring assembly (CHEBI:36820)
GNF6702 (CHEBI:133824) is a triazolopyrimidines (CHEBI:48435)
IUPAC Name
N-{4-fluoro-3-[6-(pyridin-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl}-2,4-dimethyl-1,3-oxazole-5-carboxamide
Synonyms Sources
GNF 6702 ChEBI
GNF-6702 ChEBI
Database Link Database
GNF6702 Wikipedia
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Registry Number Type Source
28255207 Reaxys Registry Number Reaxys
Citation Waiting for Citations Type Source
27501246 PubMed citation Europe PMC
Last Modified
26 October 2016