sirtinol (CHEBI:73158)

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ChEBI Name	sirtinol

ChEBI ID	CHEBI:73158

Definition	A benzamide obtained by formal condensation of the carboxy group of 2-{[(2-hydroxy-1-naphthyl)methylene]amino}benzoic acid with the amino group of 1-phenylethylamine.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Johnny Lloyd

Supplier Information

Download	Molfile XML SDF

Formula

C26H22N2O2

Net Charge

Average Mass

394.46510

Monoisotopic Mass

394.16813

InChI

InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)

InChIKey

UXJFDYIHRJGPFS-UHFFFAOYSA-N

SMILES

[H]C(=Nc1ccccc1C(=O)NC(C)c1ccccc1)c1c(O)ccc2ccccc12

Roles Classification
Biological Role(s):	EC 3.5.1.98 (histone deacetylase) inhibitor An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98). Sir2 inhibitor An EC 3.5.1.98 (histone deacetylase) inhibitor that interferes with the action of Sir2.

Application(s):	anti-inflammatory agent Any compound that has anti-inflammatory effects.

ChEBI Ontology
Outgoing	sirtinol (CHEBI:73158) has functional parent anthranilic acid (CHEBI:30754) sirtinol (CHEBI:73158) has role anti-inflammatory agent (CHEBI:67079) sirtinol (CHEBI:73158) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115) sirtinol (CHEBI:73158) has role Sir2 inhibitor (CHEBI:71181) sirtinol (CHEBI:73158) is a aldimine (CHEBI:33271) sirtinol (CHEBI:73158) is a benzamides (CHEBI:22702) sirtinol (CHEBI:73158) is a naphthols (CHEBI:25392)

IUPAC Name

2-{[(2-hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide

Registry Number	Type	Source
15029840	Reaxys Registry Number	Reaxys

Last Modified

03 June 2014