GNF6702 (CHEBI:133824)

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ChEBI Name	GNF6702

ChEBI ID	CHEBI:133824

Definition	An aromatic amide obtained by formal condensation of the carboxy group of 2,4-dimethyl-1,3-oxazole-5-carboxylic acid with the aromatic amino group of 4-fluoro-3-[6-(pyridin-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]aniline. A proteasome inhibitor known to be active against the three parasites that cause Chagas disease, leishmaniasis and sleeping sickness.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C22H16FN7O2

Net Charge

Average Mass

429.407

Monoisotopic Mass

429.13495

InChI

InChI=1S/C22H16FN7O2/c1-12-19(32-13(2)26-12)21(31)27-15-6-7-17(23)16(9-15)20-28-22-25-10-14(11-30(22)29-20)18-5-3-4-8-24-18/h3-11H,1-2H3,(H,27,31)

InChIKey

WXZFCGRYVWYYTG-UHFFFAOYSA-N

SMILES

C1(=CN2N=C(N=C2N=C1)C=3C=C(C=CC3F)NC(=O)C=4OC(=NC4C)C)C=5N=CC=CC5

Roles Classification
Biological Role(s):	antileishmanial agent An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.

Application(s):	proteasome inhibitor A drug that blocks the action of proteasomes, cellular complexes that break down proteins. antileishmanial agent An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.

ChEBI Ontology
Outgoing	GNF6702 (CHEBI:133824) has role antileishmanial agent (CHEBI:70868) GNF6702 (CHEBI:133824) has role proteasome inhibitor (CHEBI:52726) GNF6702 (CHEBI:133824) is a 1,3-oxazoles (CHEBI:46812) GNF6702 (CHEBI:133824) is a aromatic amide (CHEBI:62733) GNF6702 (CHEBI:133824) is a monofluorobenzenes (CHEBI:83575) GNF6702 (CHEBI:133824) is a pyridines (CHEBI:26421) GNF6702 (CHEBI:133824) is a ring assembly (CHEBI:36820) GNF6702 (CHEBI:133824) is a triazolopyrimidines (CHEBI:48435)

IUPAC Name

N-{4-fluoro-3-[6-(pyridin-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl}-2,4-dimethyl-1,3-oxazole-5-carboxamide

Registry Number	Type	Source
28255207	Reaxys Registry Number	Reaxys

Citation	Type	Source
27501246	PubMed citation	Europe PMC

Last Modified

26 October 2016