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> Main
CHEBI:61076 - belinostat
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ChEBI Name
belinostat
ChEBI ID
CHEBI:61076
Definition
A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
Stars
This entity has been manually annotated by the ChEBI Team.
Submitter
Sandra Orchard
Supplier Information
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Formula
C15H14N2O4S
Net Charge
0
Average Mass
318.34800
Monoisotopic Mass
318.06743
InChI
InChI=1S/C15H14N2O4S/c18-
15(16-
19)
10-
9-
12-
5-
4-
8-
14(11-
12)
22(20,21)
17-
13-
6-
2-
1-
3-
7-
13/h1-
11,17,19H,(H,16,18)
/b10-
9+
InChIKey
NCNRHFGMJRPRSK-MDZDMXLPSA-N
SMILES
ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1
Roles Classification
Biological Role
(s):
EC 3.5.1.98 (histone deacetylase) inhibitor
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
Application
(s):
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
belinostat (
CHEBI:61076
)
has role
antineoplastic agent (
CHEBI:35610
)
belinostat (
CHEBI:61076
)
has role
EC 3.5.1.98 (histone deacetylase) inhibitor (
CHEBI:61115
)
belinostat (
CHEBI:61076
)
is a
hydroxamic acid (
CHEBI:24650
)
belinostat (
CHEBI:61076
)
is a
olefinic compound (
CHEBI:78840
)
belinostat (
CHEBI:61076
)
is a
sulfonamide (
CHEBI:35358
)
IUPAC Name
(2
E
)-
N
-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide
INN
Source
belinostat
KEGG DRUG
Synonyms
Sources
(2
E
)-
N
-hydroxy-3-[3-(phenylsulfamoyl)phenyl]acrylamide
IUPAC
N-Hydroxy-3-(3-(phenylsulfamoyl)phenyl)prop-2-enamide
ChemIDplus
PXD101
SUBMITTER
Manual Xrefs
Databases
Belinostat
Wikipedia
D08870
KEGG DRUG
View more database links
Registry Numbers
Types
Sources
10087570
Reaxys Registry Number
Reaxys
414864-00-9
CAS Registry Number
ChemIDplus
Citations
Types
Sources
23382909
PubMed citation
Europe PMC
23475695
PubMed citation
Europe PMC
23644904
PubMed citation
Europe PMC
24020452
PubMed citation
Europe PMC
24369094
PubMed citation
Europe PMC
24800886
PubMed citation
Europe PMC
24918834
PubMed citation
Europe PMC
25134672
PubMed citation
Europe PMC
25189481
PubMed citation
Europe PMC
25368524
PubMed citation
Europe PMC
25389633
PubMed citation
Europe PMC
25404094
PubMed citation
Europe PMC
25433307
PubMed citation
Europe PMC
25446119
PubMed citation
Europe PMC
25483416
PubMed citation
Europe PMC
25611313
PubMed citation
Europe PMC
25673888
PubMed citation
Europe PMC
Last Modified
04 March 2015
General Comment
2011-01-25
Inhibits both class I and class II histone deacetylases. See also http://www.cancer.gov/drugdictionary/?CdrID=454583