floxuridine (CHEBI:60761)

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ChEBI Name	floxuridine

ChEBI ID	CHEBI:60761

Definition	A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C9H11FN2O5

Net Charge

Average Mass

246.19240

Monoisotopic Mass

246.06520

InChI

InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChIKey

ODKNJVUHOIMIIZ-RRKCRQDMSA-N

SMILES

OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Roles Classification
Biological Role(s):	antimetabolite A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization. antiviral drug A substance used in the prophylaxis or therapy of virus diseases.

Application(s):	radiosensitizing agent A drug that makes increases the sensitivity of tumour cells to radiation therapy. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antiviral drug A substance used in the prophylaxis or therapy of virus diseases.

ChEBI Ontology
Outgoing	floxuridine (CHEBI:60761) has role antimetabolite (CHEBI:35221) floxuridine (CHEBI:60761) has role antineoplastic agent (CHEBI:35610) floxuridine (CHEBI:60761) has role antiviral drug (CHEBI:36044) floxuridine (CHEBI:60761) has role radiosensitizing agent (CHEBI:132992) floxuridine (CHEBI:60761) is a nucleoside analogue (CHEBI:60783) floxuridine (CHEBI:60761) is a organofluorine compound (CHEBI:37143) floxuridine (CHEBI:60761) is a pyrimidine 2'-deoxyribonucleoside (CHEBI:19255)

IUPAC Name

5-fluoro-2'-deoxyuridine

Synonyms	Sources
1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil	ChemIDplus
1-beta-D-2'-Deoxyribofuranosyl-5-flurouracil	ChemIDplus
1beta-D-2'-Deoxyribofuranosyl-5-flurouracil	ChemIDplus
2'-Deoxy-5-fluorouridine	ChemIDplus
5-fluoro-2'-deoxyuridine	ChEBI
5-Fluoro-2-desoxyuridine	ChemIDplus
5-Fluorodeoxyuridine	KEGG COMPOUND
5-Fluorouracil 2'-deoxyriboside	ChemIDplus
5-Fluorouracil deoxyriboside	NIST Chemistry WebBook
5FDU	DrugBank
beta-5-Fluoro-2'-deoxyuridine	ChemIDplus
Deoxyfluorouridine	DrugBank
FdU	ChEBI
Floxuridin	ChemIDplus
Floxuridine	KEGG COMPOUND
Fluorodeoxyuridine	DrugBank
Fluoruridine deoxyribose	ChemIDplus
Fluoruridine Deoxyribose	DrugBank

Last Modified

25 May 2018