CHEBI:65513 - brasilicardin A

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name brasilicardin A
ChEBI ID CHEBI:65513
Definition A diterpenoid antibiotic isolated from the culture broth of Nocardia brasiliensis IFM0406. It exhibits antitumour and strong immunosuppressive activity.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C45H68N2O16
Net Charge 0
Average Mass 893.02520
Monoisotopic Mass 892.45688
InChI InChI=1S/C45H68N2O16/c1-20-12-13-30-44(6,25(20)17-26(58-8)31(46)39(55)56)15-14-29-43(4,5)38(54)27(18-45(29,30)7)60-42-35(53)37(36(21(2)59-42)62-40(57)23-10-9-11-24(50)16-23)63-41-32(47-22(3)49)34(52)33(51)28(19-48)61-41/h9-12,16,21,25-38,41-42,48,50-54H,13-15,17-19,46H2,1-8H3,(H,47,49)(H,55,56)/t21-,25+,26-,27-,28+,29+,30-,31-,32+,33+,34+,35+,36-,37-,38+,41-,42-,44-,45+/m0/s1
InChIKey SAZHWKBRJJLWKC-YFSQLXLCSA-N
SMILES [H][C@@]1(C[C@]2(C)[C@]([H])(CC[C@@]3(C)[C@H](C[C@H](OC)[C@H](N)C(O)=O)C(C)=CC[C@]23[H])C(C)(C)[C@@H]1O)O[C@@H]1O[C@@H](C)[C@H](OC(=O)c2cccc(O)c2)[C@@H](O[C@]2([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H]1O
Metabolite of Species Details
Nocardia brasiliensis (NCBI:txid37326) of strain IFM0406 See: PubMed
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): bacterial metabolite
Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
(via N-acetyl-D-glucosaminide )
(via D-glucosaminide )
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing brasilicardin A (CHEBI:65513) has role antimicrobial agent (CHEBI:33281)
brasilicardin A (CHEBI:65513) has role antineoplastic agent (CHEBI:35610)
brasilicardin A (CHEBI:65513) has role bacterial metabolite (CHEBI:76969)
brasilicardin A (CHEBI:65513) has role immunosuppressive agent (CHEBI:35705)
brasilicardin A (CHEBI:65513) is a N-acetyl-D-glucosaminide (CHEBI:28401)
brasilicardin A (CHEBI:65513) is a benzoate ester (CHEBI:36054)
brasilicardin A (CHEBI:65513) is a carbotricyclic compound (CHEBI:38032)
brasilicardin A (CHEBI:65513) is a diterpenoid (CHEBI:23849)
brasilicardin A (CHEBI:65513) is a non-proteinogenic α-amino acid (CHEBI:83925)
brasilicardin A (CHEBI:65513) is a phenols (CHEBI:33853)
Manual Xref Database
8638849 ChemSpider
View more database links
Registry Number Type Source
8534969 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10092191 PubMed citation Europe PMC
10724013 PubMed citation Europe PMC
11672311 PubMed citation Europe PMC
15698766 PubMed citation Europe PMC
17113997 PubMed citation Europe PMC
18503195 PubMed citation Europe PMC
21678905 PubMed citation Europe PMC
Last Modified
26 March 2015