cudratricusxanthone A (CHEBI:65686)

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ChEBI Name	cudratricusxanthone A

ChEBI ID	CHEBI:65686

Definition	A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 2, 3, 6 and 8, an isoprenyl group at position 1 and a 2-methylbut-3-en-2-yl group at position 5. It is isolated from the root barks of Cudrania tricuspidata and exhibits cytotoxicity towards human cancer cell lines.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C23H24O6

Net Charge

Average Mass

396.43310

Monoisotopic Mass

396.15729

InChI

InChI=1S/C23H24O6/c1-6-23(4,5)19-14(25)9-13(24)18-21(28)17-12(8-7-11(2)3)20(27)15(26)10-16(17)29-22(18)19/h6-7,9-10,24-27H,1,8H2,2-5H3

InChIKey

FUEJTEBWTNXAPG-UHFFFAOYSA-N

SMILES

CC(C)=CCc1c(O)c(O)cc2oc3c(c(O)cc(O)c3c(=O)c12)C(C)(C)C=C

Metabolite of Species	Details
Cudrania tricuspidata (NCBI:txid210328)	Found in root (BTO:0001188). Previous component: root bark; See: PubMed

Roles Classification
Biological Role(s):	EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. anti-inflammatory agent Any compound that has anti-inflammatory effects.

ChEBI Ontology
Outgoing	cudratricusxanthone A (CHEBI:65686) has role anti-inflammatory agent (CHEBI:67079) cudratricusxanthone A (CHEBI:65686) has role antineoplastic agent (CHEBI:35610) cudratricusxanthone A (CHEBI:65686) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544) cudratricusxanthone A (CHEBI:65686) has role metabolite (CHEBI:25212) cudratricusxanthone A (CHEBI:65686) is a polyphenol (CHEBI:26195) cudratricusxanthone A (CHEBI:65686) is a xanthones (CHEBI:51149)

IUPAC Name

2,3,6,8-tetrahydroxy-5-(2-methylbut-3-en-2-yl)-1-(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

Synonym	Source
CTXA	ChEBI

Registry Number	Type	Source
9817853	Reaxys Registry Number	Reaxys

Last Modified

19 December 2012