CHEBI:66634 - nocardione A

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ChEBI Name nocardione A
ChEBI ID CHEBI:66634
Definition A naphthofuran that is 2,3-dihydronaphtho[1,2-b]furan-4,5-dione substitutd by a hydroxy group at position 6 and a methyl group at position 2. It is isolated from Norcardia sp.TC-A0248 and acts as a protein tyrosine phosphatase inhibitor.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C13H10O4
Net Charge 0
Average Mass 230.21610
Monoisotopic Mass 230.05791
InChI InChI=1S/C13H10O4/c1-6-5-8-11(15)12(16)10-7(13(8)17-6)3-2-4-9(10)14/h2-4,6,14H,5H2,1H3/t6-/m0/s1
InChIKey FTSDAQTXFRWHEN-LURJTMIESA-N
SMILES C[C@H]1CC2=C(O1)c1cccc(O)c1C(=O)C2=O
Metabolite of Species Details
Norcardia (NCBI:txid1817) of strain TC A0248 See: PubMed
Roles Classification
Biological Role(s): EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor which interferes with the activity of the enzyme protein tyrosine phosphatases (PTPs), EC 3.1.3.48, involved in the removal of phosphate groups from phosphorylated tyrosine residues on proteins.
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing nocardione A (CHEBI:66634) has role antifungal agent (CHEBI:35718)
nocardione A (CHEBI:66634) has role antimicrobial agent (CHEBI:33281)
nocardione A (CHEBI:66634) has role EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor (CHEBI:35608)
nocardione A (CHEBI:66634) has role metabolite (CHEBI:25212)
nocardione A (CHEBI:66634) is a naphthofuran (CHEBI:39270)
nocardione A (CHEBI:66634) is a orthoquinones (CHEBI:25622)
nocardione A (CHEBI:66634) is a phenols (CHEBI:33853)
IUPAC Name
(2S)-6-hydroxy-2-methyl-2,3-dihydronaphtho[1,2-b]furan-4,5-dione
Synonym Source
(S)-(−)-nocardione A ChEBI
Registry Number Type Source
9061138 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10866214 PubMed citation Europe PMC
14587733 PubMed citation Europe PMC
15132533 PubMed citation Europe PMC
Last Modified
06 June 2016