CHEBI:132912 - nebivolol hydrochloride

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ChEBI Name nebivolol hydrochloride
ChEBI ID CHEBI:132912
Definition A racemate consisting of equal amounts of (R,S,S,S)- and (S,R,R,R)-nebivolol hydrochloride. A cardioselective beta-blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Biological Role(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
Application(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
vasodilator agent
A drug used to cause dilation of the blood vessels.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing nebivolol hydrochloride (CHEBI:132912) has part (R,S,S,S)-nebivolol hydrochloride (CHEBI:132914)
nebivolol hydrochloride (CHEBI:132912) has part (S,R,R,R)-nebivolol hydrochloride (CHEBI:132913)
nebivolol hydrochloride (CHEBI:132912) has role β-adrenergic antagonist (CHEBI:35530)
nebivolol hydrochloride (CHEBI:132912) has role antihypertensive agent (CHEBI:35674)
nebivolol hydrochloride (CHEBI:132912) has role vasodilator agent (CHEBI:35620)
nebivolol hydrochloride (CHEBI:132912) is a racemate (CHEBI:60911)
Incoming Byvalson (CHEBI:132911) has part nebivolol hydrochloride (CHEBI:132912)
IUPAC Name
rac-(1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-({(2R)-2-[(2R)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl}amino)ethan-1-ol hydrochloride
Synonyms Sources
(1RS,1'RS)-1,1'-((2RS,2'SR)-bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl))-2,2'-iminodiethanol hydrochloride ChemIDplus
nebivolol monohydrochloride ChEBI
R 67555 ChemIDplus
R-67555 ChemIDplus
Manual Xrefs Databases
D06622 KEGG DRUG
Nebivolol Wikipedia
View more database links
Registry Numbers Types Sources
152520-56-4 CAS Registry Number KEGG DRUG
4790735 Reaxys Registry Number Reaxys
Last Modified
03 August 2016