CHEBI:5119 - fluoxetine hydrochloride

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ChEBI Name fluoxetine hydrochloride
ChEBI ID CHEBI:5119
Definition A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine hydrochloride. A selective serotonin reuptake inhibitor (SSRI), it is used for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C17H19ClF3NO
Net Charge 0
Average Mass 345.78700
Monoisotopic Mass 345.11073
Roles Classification
Biological Role(s): analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
Application(s): analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
antidepressant
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing fluoxetine hydrochloride (CHEBI:5119) has part (R)-fluoxetine hydrochloride (CHEBI:86996)
fluoxetine hydrochloride (CHEBI:5119) has part (S)-fluoxetine hydrochloride (CHEBI:86997)
fluoxetine hydrochloride (CHEBI:5119) has role analgesic (CHEBI:35480)
fluoxetine hydrochloride (CHEBI:5119) has role antidepressant (CHEBI:35469)
fluoxetine hydrochloride (CHEBI:5119) has role serotonin uptake inhibitor (CHEBI:50949)
fluoxetine hydrochloride (CHEBI:5119) is a racemate (CHEBI:60911)
IUPAC Name
rac-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride
Synonyms Sources
(±)-fluoxetine HCl ChEBI
(±)-fluoxetine hydrochloride ChEBI
(±)-methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride ChemIDplus
(±)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride ChemIDplus
3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine hydrochloride ChemIDplus
fluoxetine HCl ChemIDplus
fluoxetine hydrochloride ChemIDplus
Lilly 110140 ChemIDplus
LY 110140 ChemIDplus
LY110140 ChemIDplus
rac-fluoxetine hydrochloride ChEBI
Brand Names Sources
Adofen ChemIDplus
Affectine ChemIDplus
Ansilan ChemIDplus
Deproxin ChemIDplus
Digassim ChemIDplus
Erocap ChemIDplus
Fluctin ChemIDplus
Fluctine ChemIDplus
Fludac ChemIDplus
Flufran ChemIDplus
Flunil ChemIDplus
Fluox-Puren ChemIDplus
Fluoxac ChemIDplus
Fluoxeren ChemIDplus
Fluoxil ChemIDplus
Flutin ChemIDplus
Flutine ChemIDplus
Fluxen ChemIDplus
Fluxil ChemIDplus
Fontex ChemIDplus
Foxetin ChemIDplus
Lorien ChemIDplus
Lovan ChemIDplus
Margrilan ChemIDplus
Modipran ChemIDplus
Neupax ChemIDplus
Nopres ChemIDplus
Nuzak ChemIDplus
Oxedep ChemIDplus
Pragmaten ChemIDplus
Prizma ChemIDplus
Proctin ChemIDplus
Prodep ChemIDplus
Profluzac ChemIDplus
Prozac KEGG DRUG
Reconcile ChemIDplus
Rowexetina ChemIDplus
Sanzur ChemIDplus
Sarafem ChemIDplus
Selfemra ChemIDplus
Sinzac ChemIDplus
Zactin ChemIDplus
Zepax ChemIDplus
Manual Xrefs Databases
D00823 KEGG DRUG
DB00472 DrugBank
Fluoxetine Wikipedia
View more database links
Registry Numbers Types Sources
27994391 Reaxys Registry Number Reaxys
56296-78-7 CAS Registry Number ChemIDplus
59333-67-4 CAS Registry Number KEGG DRUG
6759273 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
16121130 PubMed citation Europe PMC
19144769 PubMed citation Europe PMC
23885544 PubMed citation Europe PMC
24503458 PubMed citation Europe PMC
24615023 PubMed citation Europe PMC
24785765 PubMed citation Europe PMC
25685415 PubMed citation Europe PMC
PMC3894728 PubMed Central citation Europe PMC
Last Modified
20 July 2015