indirubin-3'-monoxime (CHEBI:43645)

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ChEBI Name	indirubin-3'-monoxime

ChEBI ID	CHEBI:43645

Definition	A member of the class of biindoles that is indirubin in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C16H11N3O2

Net Charge

Average Mass

277.278

Monoisotopic Mass

277.08513

InChI

InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,21H,(H,18,20)/b15-13-,19-14+

InChIKey

HBDSHCUSXQATPO-BGBJRWHRSA-N

SMILES

N1/C(/C(/C2=C1C=CC=C2)=N/O)=C/3\C(NC4=C3C=CC=C4)=O

Roles Classification
Biological Role(s):	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine. osteogenesis regulator Any compound that induces or regulates osteogenesis. anti-obesity agent Any substance which is used to reduce or control weight. EC 2.7.11.22 (cyclin-dependent kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22). metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. (via alkaloid )

Application(s):	neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders.

ChEBI Ontology
Outgoing	indirubin-3'-monoxime (CHEBI:43645) has role anti-obesity agent (CHEBI:74518) indirubin-3'-monoxime (CHEBI:43645) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925) indirubin-3'-monoxime (CHEBI:43645) has role EC 2.7.11.22 (cyclin-dependent kinase) inhibitor (CHEBI:82665) indirubin-3'-monoxime (CHEBI:43645) has role neuroprotective agent (CHEBI:63726) indirubin-3'-monoxime (CHEBI:43645) has role osteogenesis regulator (CHEBI:63054) indirubin-3'-monoxime (CHEBI:43645) is a alkaloid (CHEBI:22315) indirubin-3'-monoxime (CHEBI:43645) is a bisindole (CHEBI:51877) indirubin-3'-monoxime (CHEBI:43645) is a ketoxime (CHEBI:24983) indirubin-3'-monoxime (CHEBI:43645) is a oxindoles (CHEBI:38459) indirubin-3'-monoxime (CHEBI:43645) is a ring assembly (CHEBI:36820)

IUPAC Name

(3Z)-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

Synonyms	Sources
1H,1'H-[2,3']biindolylidene3,2'-dione-3-oxime	ChEBI
indirubin-3'-oxime	ChEBI

Registry Number	Type	Source
7594308	Reaxys Registry Number	Reaxys

Last Modified

30 November 2015