CHEBI:63614 - olsalazine sodium

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ChEBI Name olsalazine sodium
ChEBI ID CHEBI:63614
Definition An organic sodium salt that is the disodium salt of 3,3'-azobis(6-hydroxybenzoic acid) (olsalazine). Effective in the treatment of inflammatory bowel disease and ulcerative colitis. Mechanism of action unknown, but appears to be topical
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Anonymous
Secondary ChEBI IDs CHEBI:7771
Supplier Information
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Formula C14H8N2Na2O6
Net Charge 0
Average Mass 346.20270
Monoisotopic Mass 346.01777
InChI InChI=1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,17-18H,(H,19,20)(H,21,22);;/q;2*+1/p-2
InChIKey ZJEFYLVGGFISGT-UHFFFAOYSA-L
SMILES [Na+].[Na+].Oc1ccc(cc1C([O-])=O)N=Nc1ccc(O)c(c1)C([O-])=O
Roles Classification
Application(s): non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
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ChEBI Ontology
Outgoing olsalazine sodium (CHEBI:63614) has part olsalazine(2−) (CHEBI:63719)
olsalazine sodium (CHEBI:63614) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
olsalazine sodium (CHEBI:63614) has role prodrug (CHEBI:50266)
olsalazine sodium (CHEBI:63614) is a organic sodium salt (CHEBI:38700)
IUPAC Name
disodium 3,3'-diazene-1,2-diylbis(6-hydroxybenzoate)
Synonyms Sources
disodium 3,3'-azobis (6-hydroxybenzoate) ChEBI
Disodium 5,5'-azodisalicylate ChemIDplus
Manual Xrefs Databases
D00727 KEGG DRUG
DB01250 DrugBank
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Registry Numbers Types Sources
6054-98-4 CAS Registry Number KEGG DRUG
6054-98-4 CAS Registry Number ChemIDplus
9027885 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
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Last Modified
10 April 2013