CHEBI:78766 - LLP-3

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ChEBI Name LLP-3
ChEBI ID CHEBI:78766
Definition A pyridone that is pyridin-2(1H)-one which is substituted at positions 3, 4, and 6 by cyano, 3,5-bis(benzyloxy)phenyl, and 5-chloro-2-hydroxyphenyl groups, respectively. It is an inhibitor for Survivin-Ran protein complex.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Margaret Duesbury
Supplier Information
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Formula C32H23ClN2O4
Net Charge 0
Average Mass 534.98900
Monoisotopic Mass 534.13463
InChI InChI=1S/C32H23ClN2O4/c33-24-11-12-31(36)28(15-24)30-17-27(29(18-34)32(37)35-30)23-13-25(38-19-21-7-3-1-4-8-21)16-26(14-23)39-20-22-9-5-2-6-10-22/h1-17,36H,19-20H2,(H,35,37)
InChIKey NZRBRJQYGLEINZ-UHFFFAOYSA-N
SMILES Oc1ccc(Cl)cc1-c1cc(-c2cc(OCc3ccccc3)cc(OCc3ccccc3)c2)c(C#N)c(=O)[nH]1
Roles Classification
Biological Role(s): inhibitor
A substance that diminishes the rate of a chemical reaction.
survivin dimerisation modulator
Any compound that affects the dimerisation of the protein survivin.
antimitotic
Any compound that inhibits cell division (mitosis).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing LLP-3 (CHEBI:78766) has role antimitotic (CHEBI:64911)
LLP-3 (CHEBI:78766) has role antineoplastic agent (CHEBI:35610)
LLP-3 (CHEBI:78766) has role inhibitor (CHEBI:35222)
LLP-3 (CHEBI:78766) has role survivin dimerisation modulator (CHEBI:78926)
LLP-3 (CHEBI:78766) is a aromatic ether (CHEBI:35618)
LLP-3 (CHEBI:78766) is a benzyl ether (CHEBI:59859)
LLP-3 (CHEBI:78766) is a hydroxynitrile (CHEBI:24730)
LLP-3 (CHEBI:78766) is a monochlorobenzenes (CHEBI:83403)
LLP-3 (CHEBI:78766) is a phenols (CHEBI:33853)
LLP-3 (CHEBI:78766) is a pyridone (CHEBI:38183)
IUPAC Name
4-[3,5-bis(benzyloxy)phenyl]-6-(5-chloro-2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
Synonym Source
LLP3 ChEBI
Registry Number Type Source
23916493 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
23251006 PubMed citation SUBMITTER
23968825 PubMed citation Europe PMC
Last Modified
23 October 2014