caerulomycinonitrile (CHEBI:69234)

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ChEBI Name	caerulomycinonitrile

ChEBI ID	CHEBI:69234

Definition	A pyridine alkaloid that is 2,2ʼ-bipyridine-6-carbonitrile substituted by a methoxy group at position 4. Isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus, it exhibits antineoplastic activity.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formula

C12H9N3O

Net Charge

Average Mass

211.21940

Monoisotopic Mass

211.07456

InChI

InChI=1S/C12H9N3O/c1-16-10-6-9(8-13)15-12(7-10)11-4-2-3-5-14-11/h2-7H,1H3

InChIKey

UEBDZDZLEVYUEC-UHFFFAOYSA-N

SMILES

COc1cc(nc(c1)-c1ccccn1)C#N

Metabolite of Species	Details
Actinoalloteichus cyanogriseus (NCBI:txid65497)	Ethyl acetate extract of fermentation broth of strain WH1 2216-6 See: PubMed

Roles Classification
Biological Role(s):	bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. marine metabolite Any metabolite produced during a metabolic reaction in marine macro- and microorganisms. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. (via alkaloid )

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	caerulomycinonitrile (CHEBI:69234) has parent hydride 2,2'-bipyridine (CHEBI:30351) caerulomycinonitrile (CHEBI:69234) has role antineoplastic agent (CHEBI:35610) caerulomycinonitrile (CHEBI:69234) has role bacterial metabolite (CHEBI:76969) caerulomycinonitrile (CHEBI:69234) has role marine metabolite (CHEBI:76507) caerulomycinonitrile (CHEBI:69234) is a aromatic ether (CHEBI:35618) caerulomycinonitrile (CHEBI:69234) is a bipyridines (CHEBI:50511) caerulomycinonitrile (CHEBI:69234) is a nitrile (CHEBI:18379) caerulomycinonitrile (CHEBI:69234) is a pyridine alkaloid (CHEBI:26416)

IUPAC Name

4-methoxy-2,2ʼ-bipyridine-6-carbonitrile

Registry Number	Type	Source
521868	Reaxys Registry Number	Reaxys

Citation	Type	Source
21770434	PubMed citation	Europe PMC

Last Modified

02 December 2013