droxidopa (CHEBI:31524)

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ChEBI Name	droxidopa

ChEBI ID	CHEBI:31524

Definition	A serine derivative that is L-serine substituted at the β-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C9H11NO5

Net Charge

Average Mass

213.18730

Monoisotopic Mass

213.06372

InChI

InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1

InChIKey

QXWYKJLNLSIPIN-JGVFFNPUSA-N

SMILES

N[C@@H]([C@H](O)c1ccc(O)c(O)c1)C(O)=O

Roles Classification
Application(s):	prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. vasoconstrictor agent Drug used to cause constriction of the blood vessels. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.

ChEBI Ontology
Outgoing	droxidopa (CHEBI:31524) has role antihypertensive agent (CHEBI:35674) droxidopa (CHEBI:31524) has role prodrug (CHEBI:50266) droxidopa (CHEBI:31524) has role vasoconstrictor agent (CHEBI:50514) droxidopa (CHEBI:31524) is a L-tyrosine derivative (CHEBI:27177) droxidopa (CHEBI:31524) is a catechols (CHEBI:33566)

IUPAC Name

(βR)-β,3-dihydroxy-L-tyrosine

Synonyms	Sources
(−)-(2S,3R)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid	ChEBI
(2S,3R)-3,4-dihydroxy-phenylserine	ChEBI
Droxydopa	HMDB
L-Dihydroxyphenylserine	DrugBank
L-DOPS	DrugBank
L-threo-dihydroxyphenylserine	DrugBank
L-Threodops	ChemIDplus
SM 5688	ChemIDplus
threo-Dopaserine	ChemIDplus

Last Modified

26 January 2023