aminophylline (CHEBI:2659)

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ChEBI Name	aminophylline

ChEBI ID	CHEBI:2659

Definition	A mixture comprising of theophylline and ethylenediamine in a 2:1 ratio.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C7H8N4O2.C7H8N4O2.C2H8N2

Net Charge

Average Mass

420.434

Monoisotopic Mass

420.19820

InChI

InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2

InChIKey

FQPFAHBPWDRTLU-UHFFFAOYSA-N

SMILES

NCCN.CN1C2=C(NC=N2)C(=O)N(C)C1=O.CN1C2=C(NC=N2)C(=O)N(C)C1=O

Roles Classification
Application(s):	cardiotonic drug A drug that has a strengthening effect on the heart or that can increase cardiac output. bronchodilator agent An agent that causes an increase in the expansion of a bronchus or bronchial tubes.

ChEBI Ontology
Outgoing	aminophylline (CHEBI:2659) has part ethylenediamine (CHEBI:30347) aminophylline (CHEBI:2659) has part theophylline (CHEBI:28177) aminophylline (CHEBI:2659) has role bronchodilator agent (CHEBI:35523) aminophylline (CHEBI:2659) has role cardiotonic drug (CHEBI:38147) aminophylline (CHEBI:2659) is a mixture (CHEBI:60004)

IUPAC Name

1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - ethane-1,2-diamine (2:1)

Synonyms	Sources
3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, compd with 1,2-ethanediamine (2:1)	ChemIDplus
Aminophylline	KEGG DRUG
BY 108	ChemIDplus
ethylenediamine, compd. with theophylline (1:2)	ChemIDplus
TAD	ChemIDplus
TH/100	ChemIDplus
theophyline ethylenediamine	ChemIDplus
theophylline, compd with ethylenediamine (2:1)	ChemIDplus

Brand Names	Sources
Aminocardol	ChemIDplus
Aminodur	ChemIDplus
Aminodur dura-tabs	ChemIDplus
Aminofillina	ChemIDplus
Aminophyllin	ChemIDplus
Cardiofilina	ChemIDplus
Cardiomin	ChemIDplus
Cardophylin	ChemIDplus
Cardophyllin	ChemIDplus
Carena	ChemIDplus
Cariomin	ChemIDplus
Diaphilline	ChemIDplus
Diaphylline	ChemIDplus
Diophllin	ChemIDplus
Diophyllin	ChemIDplus
Diuxanthine	ChemIDplus
Dobo	ChemIDplus
Ethophylline	ChemIDplus
Etilen-Xantisan	ChemIDplus
Eufilina	ChemIDplus
Euphyllin	ChemIDplus
Euphylline	ChemIDplus
Euphyllinum	ChemIDplus
Eurphyllin	ChemIDplus
Euufilin	ChemIDplus
Euufillin	ChemIDplus
Genophyllin	ChemIDplus
Grifomin	ChemIDplus
Inophylline	ChemIDplus
Lasodex	ChemIDplus
Linampheta	ChemIDplus
Lixaminol	ChemIDplus
Metaphyllin	ChemIDplus
Metaphylline	ChemIDplus
Methophylline	ChemIDplus
Minaphil	ChemIDplus
Miofilin	ChemIDplus
Neophyiline	ChemIDplus
Neophylline	ChemIDplus
Norofilina	ChemIDplus
Peterphyllin	ChemIDplus
Phylcardin	ChemIDplus
Phyllindon	ChemIDplus
Phyllocontin	ChemIDplus
Rectalad aminophylline	ChemIDplus
Somophyllin	KEGG DRUG
Stenovasan	ChemIDplus
Syntophyllin	ChemIDplus
Tefamin	ChemIDplus
Theodrox	ChemIDplus
Theolamine	ChemIDplus
Theolone	ChemIDplus
Theomin	ChemIDplus
Theophyldine	ChemIDplus
Theophyline ethylenediamine	ChemIDplus
Theophyllamine	ChemIDplus
Theophyllaminium	ChemIDplus
Theophyllaminum	ChemIDplus
Theophyllin aethylendiamin	ChemIDplus
Theophylline ethylenediamine	KEGG DRUG
Thephyldine	ChemIDplus
Truphylline	ChemIDplus
Variaphylline	ChemIDplus
Vasofilina	ChemIDplus

Last Modified

16 February 2024

General Comment
2020-01-28	A drug combination containing theophylline and ethylenediamine, it has similar pharmacologic actions to theophylline. It is most commonly used to treat bronchial asthma, but has been investigated for several other applications.