CHEBI:90683 - talmapimod

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name talmapimod
ChEBI ID CHEBI:90683
Definition An indolecarboxamide obtained by formal condensation of the carboxy group of 6-chloro-3-[(dimethylamino)(oxo)acetyl]-1-methylindole-5-carboxylic acid with the secondary amino group of (2S,5R)-1-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine. It is a potent inhibitor of MAPK and exhibits anti-cancer properties.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Matthias Ziehm
Supplier Information
Download Molfile XML SDF
Formula C27H30ClFN4O3
Net Charge 0
Average Mass 513.004
Monoisotopic Mass 512.19905
InChI InChI=1S/C27H30ClFN4O3/c1-16-13-33(17(2)12-32(16)14-18-6-8-19(29)9-7-18)26(35)21-10-20-22(25(34)27(36)30(3)4)15-31(5)24(20)11-23(21)28/h6-11,15-17H,12-14H2,1-5H3/t16-,17+/m0/s1
InChIKey ZMELOYOKMZBMRB-DLBZAZTESA-N
SMILES CN(C)C(C(=O)C=1C=2C=C(C(=CC2N(C1)C)Cl)C(=O)N3[C@H](C)CN([C@H](C3)C)CC4=CC=C(F)C=C4)=O
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24).
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing talmapimod (CHEBI:90683) has role antineoplastic agent (CHEBI:35610)
talmapimod (CHEBI:90683) has role apoptosis inducer (CHEBI:68495)
talmapimod (CHEBI:90683) has role EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor (CHEBI:79091)
talmapimod (CHEBI:90683) is a N-acylpiperazine (CHEBI:46844)
talmapimod (CHEBI:90683) is a N-alkylpiperazine (CHEBI:46845)
talmapimod (CHEBI:90683) is a aromatic amide (CHEBI:62733)
talmapimod (CHEBI:90683) is a aromatic ketone (CHEBI:76224)
talmapimod (CHEBI:90683) is a chloroindole (CHEBI:52508)
talmapimod (CHEBI:90683) is a dicarboxylic acid diamide (CHEBI:35779)
talmapimod (CHEBI:90683) is a indolecarboxamide (CHEBI:46921)
talmapimod (CHEBI:90683) is a monofluorobenzenes (CHEBI:83575)
IUPAC Name
2-(6-chloro-5-{(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine-1-carbonyl}-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide
INN Source
talmapimod KEGG DRUG
Synonyms Sources
SCIO 469 ChemIDplus
SCIO-469 ChemIDplus
SCIO469 ChEBI
Scios 469 ChemIDplus
Manual Xrefs Databases
469 PDBeChem
D09386 KEGG DRUG
View more database links
Registry Numbers Types Sources
11328447 Reaxys Registry Number Reaxys
309913-83-5 CAS Registry Number ChemIDplus
309913-83-5 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
20201574 PubMed citation Europe PMC
21659629 PubMed citation Europe PMC
22868770 PubMed citation Europe PMC
23032694 PubMed citation Europe PMC
23841999 PubMed citation Europe PMC
25749612 PubMed citation Europe PMC
Last Modified
05 January 2016