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ChEBI
> Main
CHEBI:63334 - rolitetracycline
Main
ChEBI Ontology
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ChEBI Name
rolitetracycline
ChEBI ID
CHEBI:63334
Definition
A derivative of tetracycline in which the amide function is substituted with a pyrrolidinomethyl group.
Stars
This entity has been manually annotated by the ChEBI Team.
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Read full article at Wikipedia
Formula
C27H33N3O8
Net Charge
0
Average Mass
527.56620
Monoisotopic Mass
527.22677
InChI
InChI=1S/C27H33N3O8/c1-
26(37)
13-
7-
6-
8-
16(31)
17(13)
21(32)
18-
14(26)
11-
15-
20(29(2)
3)
22(33)
19(24(35)
27(15,38)
23(18)
34)
25(36)
28-
12-
30-
9-
4-
5-
10-
30/h6-
8,14-
15,20,31,33-
34,37-
38H,4-
5,9-
12H2,1-
3H3,(H,28,36)
/t14-
,15-
,20-
,26+,27-
/m0/s1
InChIKey
HMEYVGGHISAPJR-IAHYZSEUSA-N
SMILES
[H]
[C@@]
12C[C@@]
3([H]
)
C(C(=O)
c4c(O)
cccc4[C@@]
3(C)
O)
=C(O)
[C@]
1(O)
C(=O)
C(C(=O)
NCN1CCCC1)
=C(O)
[C@H]
2N(C)
C
Roles Classification
Biological Role
(s):
antibacterial drug
A drug used to treat or prevent bacterial infections.
protein synthesis inhibitor
A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
antiprotozoal drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via
tetracyclines
)
Application
(s):
antibacterial drug
A drug used to treat or prevent bacterial infections.
antiprotozoal drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
rolitetracycline (
CHEBI:63334
)
has role
antibacterial drug (
CHEBI:36047
)
rolitetracycline (
CHEBI:63334
)
has role
antiprotozoal drug (
CHEBI:35820
)
rolitetracycline (
CHEBI:63334
)
has role
prodrug (
CHEBI:50266
)
rolitetracycline (
CHEBI:63334
)
has role
protein synthesis inhibitor (
CHEBI:48001
)
rolitetracycline (
CHEBI:63334
)
is a
tertiary α-hydroxy ketone (
CHEBI:139592
)
rolitetracycline (
CHEBI:63334
)
is a
tetracyclines (
CHEBI:26895
)
IUPAC Name
(4
S
,4a
S
,5a
S
,6
S
,12a
S
)-
4-
(dimethylamino)-
3,6,10,12,12a-
pentahydroxy-
6-
methyl-
1,11-
dioxo-
N
-
(pyrrolidin-
1-
ylmethyl)-
1,4,4a,5,5a,6,11,12a-
octahydrotetracene-
2-
carboxamide
INNs
Sources
rolitetraciclina
ChemIDplus
rolitetracycline
KEGG DRUG
rolitetracyclinum
ChemIDplus
Synonyms
Sources
N-(1-Pyrrolidinylmethyl)-tetracycline
ChemIDplus
N-(Pyrrolidinomethyl)tetracycline
ChemIDplus
Pyrrolidino-methyl-tetracycline
ChemIDplus
Reverin
ChemIDplus
Brand Name
Source
Synterin
KEGG DRUG
Manual Xrefs
Databases
2399
DrugCentral
D02282
KEGG DRUG
DB01301
DrugBank
Rolitetracycline
Wikipedia
US3104240
Patent
View more database links
Registry Numbers
Types
Sources
73191
Reaxys Registry Number
Reaxys
751-97-3
CAS Registry Number
ChemIDplus
751-97-3
CAS Registry Number
KEGG DRUG
Citation
Type
Source
1650428
PubMed citation
Europe PMC
Last Modified
07 February 2018