CHEBI:66092 - isochamuvaritin

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ChEBI Name isochamuvaritin
ChEBI ID CHEBI:66092
Definition A member of the class of a xanthenes that is 9H-xanthene substituted by hydroxy groups at positions 1 and 3, a 2-hydroxybenzyl group at position 2 and a 3-phenylpropanoyl group at position 4. Isolated from the roots of Uvaria acuminata, it exhibits potent cytotoxicity against human promyelocytic leukemia HL-60 cells.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C29H24O5
Net Charge 0
Average Mass 452.49790
Monoisotopic Mass 452.16237
InChI InChI=1S/C29H24O5/c30-23-12-6-4-10-19(23)16-21-27(32)22-17-20-11-5-7-13-25(20)34-29(22)26(28(21)33)24(31)15-14-18-8-2-1-3-9-18/h1-13,30,32-33H,14-17H2
InChIKey VBENIJLFKRPAAF-UHFFFAOYSA-N
SMILES Oc1ccccc1Cc1c(O)c2Cc3ccccc3Oc2c(C(=O)CCc2ccccc2)c1O
Metabolite of Species Details
Uvaria acuminata (NCBI:txid672960) Found in root (BTO:0001188). See: PubMed
Roles Classification
Biological Role(s): metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing isochamuvaritin (CHEBI:66092) has role antineoplastic agent (CHEBI:35610)
isochamuvaritin (CHEBI:66092) has role metabolite (CHEBI:25212)
isochamuvaritin (CHEBI:66092) is a dihydrochalcones (CHEBI:71230)
isochamuvaritin (CHEBI:66092) is a polyphenol (CHEBI:26195)
isochamuvaritin (CHEBI:66092) is a xanthenes (CHEBI:38835)
IUPAC Name
1-[1,3-dihydroxy-2-(2-hydroxybenzyl)-9H-xanthen-4-yl]-3-phenylpropan-1-one
Registry Number Type Source
9739285 Reaxys Registry Number Reaxys
Citation Waiting for Citations Type Source
14709883 PubMed citation Europe PMC
Last Modified
04 March 2013