CHEBI:71658 - mersacidin

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ChEBI Name mersacidin
ChEBI ID CHEBI:71658
Definition A type-B lantibiotic containing 3-methyllanthionine and S-(2-aminovinyl)-3-methylcysteine residues and four intra-chain thioether bridges. It is obtained from Bacillus sp. HIL Y-85,54728 and is active in vivo against methicillin-resistant Staphylococcus aureus (MRSA).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C80H120N20O21S4
Net Charge 0
Average Mass 1826.19000
Monoisotopic Mass 1824.78198
InChI InChI=1S/C80H120N20O21S4/c1-14-40(8)61-74(115)82-24-26-122-42(10)62-76(117)87-41(9)66(107)88-48(22-23-59(105)106)68(109)92-52(71(112)95-61)35-124-44(12)64(78(119)89-49(27-37(2)3)69(110)97-62)99-72(113)53-36-125-45(13)65(98-70(111)50(29-46-19-16-15-17-20-46)90-77(118)63-43(11)123-34-47(81)67(108)96-63)79(120)91-51(28-38(4)5)80(121)100-25-18-21-54(100)73(114)86-32-57(103)84-30-55(101)83-31-56(102)85-33-58(104)94-60(39(6)7)75(116)93-53/h15-17,19-20,24,26,37-40,42-45,47-54,60-65H,9,14,18,21-23,25,27-36,81H2,1-8,10-13H3,(H,82,115)(H,83,101)(H,84,103)(H,85,102)(H,86,114)(H,87,117)(H,88,107)(H,89,119)(H,90,118)(H,91,120)(H,92,109)(H,93,116)(H,94,104)(H,95,112)(H,96,108)(H,97,110)(H,98,111)(H,99,113)(H,105,106)/b26-24+/t40-,42+,43+,44+,45+,47+,48+,49+,50+,51+,52+,53+,54+,60+,61+,62?,63-,64-,65-/m1/s1
InChIKey JSWKNDSDVHJUKY-CYGWNLPQSA-N
SMILES [H][C@@]1(C)SC[C@@H]2NC(=O)[C@H](CCC(O)=O)NC(=O)C(=C)NC(=O)C(NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1NC(=O)[C@@H]1CS[C@@H](C)[C@@]([H])(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@]3([H])NC(=O)[C@@H](N)CS[C@H]3C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N3CCC[C@@]3([H])C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N1)[C@H](C)S\C=C\NC(=O)[C@@]([H])(NC2=O)[C@H](C)CC
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antibacterial agent
A substance (or active part thereof) that kills or slows the growth of bacteria.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
(via peptide antibiotic )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing mersacidin (CHEBI:71658) has role antibacterial agent (CHEBI:33282)
mersacidin (CHEBI:71658) has role metabolite (CHEBI:25212)
mersacidin (CHEBI:71658) is a macrocycle (CHEBI:51026)
mersacidin (CHEBI:71658) is a type B lantibiotic (CHEBI:71647)
mersacidin (CHEBI:71658) is tautomer of mersacidin zwitterion (CHEBI:91014)
Incoming mersacidin zwitterion (CHEBI:91014) is tautomer of mersacidin (CHEBI:71658)
IUPAC Name
3-{(4S,7S,8S,11R,14S,17E,20S,26S)-7-[({(15S,18R,21S,22S,25S,30aS)-22-[(N-{[(2S,3S,6R)-6-amino-2-methyl-5-oxo-1,4-thiazepan-3-yl]carbonyl}-L-phenylalanyl)amino]-25-isobutyl-15-isopropyl-21-methyl-1,4,7,10,13,16,23,26-octaoxooctacosahydro-1H-pyrrolo[2,1-u][1,4,7,10,13,16,19,22,25]thiaoctaazacyclooctacosin-18-yl}carbonyl)amino]-14-[(2R)-butan-2-yl]-4-isobutyl-8,20-dimethyl-23-methylene-3,6,12,15,21,24,27-heptaoxo-9,19-dithia-2,5,13,16,22,25,28-heptaazabicyclo[9.9.8]octacos-17-en-26-yl}propanoic acid
Synonym Source
M87-1551 ChEBI
Registry Numbers Types Sources
128104-18-7 CAS Registry Number ChemIDplus
8197141 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10818347 PubMed citation Europe PMC
10831439 PubMed citation Europe PMC
1500347 PubMed citation Europe PMC
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15282239 PubMed citation Europe PMC
1649577 PubMed citation Europe PMC
16980420 PubMed citation Europe PMC
21811596 PubMed citation Europe PMC
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22628498 PubMed citation Europe PMC
7737474 PubMed citation Europe PMC
Last Modified
25 January 2013