pyridoxamine dihydrochloride (CHEBI:131532)

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ChEBI Name	pyridoxamine dihydrochloride

ChEBI ID	CHEBI:131532

Definition	A hydrochloride obtained by combining pyridoxamine with two molar equivalents of hydrochloric acid. Used for treatment of diabetic nephropathy.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C8H14Cl2N2O2

Net Charge

Average Mass

241.115

Monoisotopic Mass

240.04323

InChI

InChI=1S/C8H12N2O2.2ClH/c1-5-8(12)7(2-9)6(4-11)3-10-5;;/h3,11-12H,2,4,9H2,1H3;2*1H

InChIKey

HNWCOANXZNKMLR-UHFFFAOYSA-N

SMILES

C1(O)=C(C)N=CC(CO)=C1CN.Cl.Cl

Roles Classification
Chemical Role(s):	iron chelator

Biological Role(s):	mouse metabolite Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus). plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). Escherichia coli metabolite Any bacterial metabolite produced during a metabolic reaction in Escherichia coli. Saccharomyces cerevisiae metabolite Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ). water-soluble vitamin (role) Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine. (via B vitamin )

Application(s):	nephroprotective agent Any protective agent that is able to prevent damage to the kidney. nutraceutical A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance. (via B vitamin )

ChEBI Ontology
Outgoing	pyridoxamine dihydrochloride (CHEBI:131532) has part pyridoxamine(2+) (CHEBI:131533) pyridoxamine dihydrochloride (CHEBI:131532) has role Escherichia coli metabolite (CHEBI:76971) pyridoxamine dihydrochloride (CHEBI:131532) has role Saccharomyces cerevisiae metabolite (CHEBI:75772) pyridoxamine dihydrochloride (CHEBI:131532) has role human metabolite (CHEBI:77746) pyridoxamine dihydrochloride (CHEBI:131532) has role iron chelator (CHEBI:38157) pyridoxamine dihydrochloride (CHEBI:131532) has role mouse metabolite (CHEBI:75771) pyridoxamine dihydrochloride (CHEBI:131532) has role nephroprotective agent (CHEBI:76595) pyridoxamine dihydrochloride (CHEBI:131532) has role plant metabolite (CHEBI:76924) pyridoxamine dihydrochloride (CHEBI:131532) is a hydrochloride (CHEBI:36807) pyridoxamine dihydrochloride (CHEBI:131532) is a vitamin B₆ (CHEBI:27306)

IUPAC Names

4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol dihydrochloride

4-(azaniumylmethyl)-3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-1-ium dichloride

Synonyms	Sources
2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridene dihydrochloride	ChemIDplus
4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride	ChemIDplus
pyridoxamine 2HCl	ChEBI
Pyridoxamine dichlorohydrate	ChemIDplus
Pyridoxylamine dihydrochloride	ChemIDplus

Citation	Type	Source
25532068	PubMed citation	Europe PMC

Last Modified

22 July 2021