CHEBI:6439 - levobunolol hydrochloride

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ChEBI Name levobunolol hydrochloride
ChEBI ID CHEBI:6439
Definition A hydrochloride obtained by combining equimolar amounts of levobunolol and hydrochloric acid. A non-selective β-adrenergic antagonist used for treatment of glaucoma.
Stars This entity has been manually annotated by the ChEBI Team.
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Formulae C17H25NO3.HCl
C17H26ClNO3
Net Charge 0
Average Mass 327.84600
Monoisotopic Mass 327.16012
InChI InChI=1S/C17H25NO3.ClH/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20;/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3;1H/t12-;/m0./s1
InChIKey DNTDOBSIBZKFCP-YDALLXLXSA-N
SMILES Cl.CC(C)(C)NC[C@H](O)COc1cccc2C(=O)CCCc12
Roles Classification
Biological Role(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
Application(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
antiglaucoma drug
Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
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ChEBI Ontology
Outgoing levobunolol hydrochloride (CHEBI:6439) has part levobunolol(1+) (CHEBI:72567)
levobunolol hydrochloride (CHEBI:6439) has role β-adrenergic antagonist (CHEBI:35530)
levobunolol hydrochloride (CHEBI:6439) has role antiglaucoma drug (CHEBI:39456)
levobunolol hydrochloride (CHEBI:6439) is a hydrochloride (CHEBI:36807)
IUPAC Name
5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydronaphthalen-1(2H)-one hydrochloride
Synonyms Sources
(-)-3,4-Dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone hydrochloride ChemIDplus
(-)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone hydrochloride ChemIDplus
(2S)-N-(tert-butyl)-2-hydroxy-3-[(5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy]propan-1-aminium chloride IUPAC
Levobunolol HCl ChemIDplus
Levobunolol hydrochloride KEGG COMPOUND
levobunolol monohydrochloride ChEBI
Brand Name Source
Betagan KEGG DRUG
Manual Xrefs Databases
C08228 KEGG COMPOUND
CN101342163 Patent
D01025 KEGG DRUG
DB01210 DrugBank
Levobunolol Wikipedia
US5733938 Patent
US6159458 Patent
WO2007034140 Patent
WO2008002929 Patent
View more database links
Registry Number Type Source
27912-14-7 CAS Registry Number ChemIDplus
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Last Modified
21 February 2013