CHEBI:67357 - dolastatin 10

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name dolastatin 10
ChEBI ID CHEBI:67357
Definition A tetrapeptide that is isolated from the sea hare Dolabella auricularia. It is a potent anticancer agent which inhibits tubulin polymerization.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:4684
Download Molfile XML SDF
more structures >>
Formula C42H68N6O6S
Net Charge 0
Average Mass 785.100
Monoisotopic Mass 784.49211
Metabolite of Species Details
Dolabella auricularia (NCBI:txid6511) See: PubMed
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): animal metabolite
Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
marine metabolite
Any metabolite produced during a metabolic reaction in marine macro- and microorganisms.
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
microtubule-destabilising agent
Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing dolastatin 10 (CHEBI:67357) has functional parent L-valine (CHEBI:16414)
dolastatin 10 (CHEBI:67357) has role animal metabolite (CHEBI:75767)
dolastatin 10 (CHEBI:67357) has role antineoplastic agent (CHEBI:35610)
dolastatin 10 (CHEBI:67357) has role apoptosis inducer (CHEBI:68495)
dolastatin 10 (CHEBI:67357) has role marine metabolite (CHEBI:76507)
dolastatin 10 (CHEBI:67357) has role microtubule-destabilising agent (CHEBI:61951)
dolastatin 10 (CHEBI:67357) is a 1,3-thiazoles (CHEBI:38418)
dolastatin 10 (CHEBI:67357) is a tetrapeptide (CHEBI:48030)
IUPAC Name
N,N-dimethyl-L-valyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide
Synonyms Sources
DLS-10 ChEBI
dolastatin-10 ChemIDplus
Manual Xrefs Databases
7986684 ChemSpider
C00044726 KNApSAcK
C11280 KEGG COMPOUND
DB12730 DrugBank
LSM-45943 LINCS
View more database links
Registry Numbers Types Sources
110417-88-4 CAS Registry Number KEGG COMPOUND
110417-88-4 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
21472238 PubMed citation Europe PMC
21534541 PubMed citation Europe PMC
2353935 PubMed citation Europe PMC
25431858 PubMed citation Europe PMC
28682414 PubMed citation Europe PMC
28885014 PubMed citation Europe PMC
29454703 PubMed citation Europe PMC
30023909 PubMed citation Europe PMC
31460552 PubMed citation Europe PMC
31830440 PubMed citation Europe PMC
32026730 PubMed citation Europe PMC
32323990 PubMed citation Europe PMC
8471072 PubMed citation Europe PMC
Last Modified
15 January 2021