tyrphostin B42 (CHEBI:131968)

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ChEBI Name	tyrphostin B42

ChEBI ID	CHEBI:131968

Definition	A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Ceri

Supplier Information

Download	Molfile XML SDF

Formula

C17H14N2O3

Net Charge

Average Mass

294.305

Monoisotopic Mass

294.10044

InChI

InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+

InChIKey

TUCIOBMMDDOEMM-RIYZIHGNSA-N

SMILES

C=1(C=CC(=CC1O)/C=C(/C(NCC=2C=CC=CC2)=O)\C#N)O

Roles Classification
Chemical Role(s):	antioxidant A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.

Biological Role(s):	EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2). STAT3 inhibitor An inhibitor of signal transducer and activator of transcription 3 (STAT3) apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

Application(s):	anti-inflammatory agent Any compound that has anti-inflammatory effects. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.

ChEBI Ontology
Outgoing	tyrphostin B42 (CHEBI:131968) has role anti-inflammatory agent (CHEBI:67079) tyrphostin B42 (CHEBI:131968) has role antioxidant (CHEBI:22586) tyrphostin B42 (CHEBI:131968) has role apoptosis inducer (CHEBI:68495) tyrphostin B42 (CHEBI:131968) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617) tyrphostin B42 (CHEBI:131968) has role geroprotector (CHEBI:176497) tyrphostin B42 (CHEBI:131968) has role STAT3 inhibitor (CHEBI:87183) tyrphostin B42 (CHEBI:131968) is a catechols (CHEBI:33566) tyrphostin B42 (CHEBI:131968) is a enamide (CHEBI:51751) tyrphostin B42 (CHEBI:131968) is a monocarboxylic acid amide (CHEBI:29347) tyrphostin B42 (CHEBI:131968) is a nitrile (CHEBI:18379) tyrphostin B42 (CHEBI:131968) is a secondary carboxamide (CHEBI:140325)

IUPAC Name

(2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide

Last Modified

27 October 2021