CHEBI:66279 - tubelactomicin A

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ChEBI Name tubelactomicin A
ChEBI ID CHEBI:66279
Definition A 16-membered macrolide which exhibits strong and specific antimicrobial activities against rapid-growing Mycobacteria including drug-resistant strains. It is isolated from the culture broth of Nocardia sp.MK703-102F1
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C29H42O6
Net Charge 0
Average Mass 486.64020
Monoisotopic Mass 486.29814
InChI InChI=1S/C29H42O6/c1-17-10-6-9-13-23-19(3)16-22-24(15-14-18(2)26(22)31)29(23,5)28(34)35-20(4)11-7-8-12-21(25(17)30)27(32)33/h6,9-10,12-13,16-18,20,22-26,30-31H,7-8,11,14-15H2,1-5H3,(H,32,33)/b10-6+,13-9+,21-12-/t17-,18-,20+,22+,23-,24-,25+,26+,29-/m0/s1
InChIKey LWPAZPOZBPFAAE-WSQSGNSCSA-N
SMILES [H][C@@]12C=C(C)[C@]3([H])\C=C\C=C\[C@H](C)[C@@H](O)\C(=C\CCC[C@@H](C)OC(=O)[C@]3(C)[C@@]1([H])CC[C@H](C)[C@H]2O)C(O)=O
Metabolite of Species Details
Nocardia (NCBI:txid1821) of strain MK 703-102F1 See: PubMed
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
antitubercular agent
A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
Application(s): antitubercular agent
A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing tubelactomicin A (CHEBI:66279) has role antimicrobial agent (CHEBI:33281)
tubelactomicin A (CHEBI:66279) has role antitubercular agent (CHEBI:33231)
tubelactomicin A (CHEBI:66279) has role metabolite (CHEBI:25212)
tubelactomicin A (CHEBI:66279) is a macrolide (CHEBI:25106)
tubelactomicin A (CHEBI:66279) is a monocarboxylic acid (CHEBI:25384)
tubelactomicin A (CHEBI:66279) is a secondary alcohol (CHEBI:35681)
IUPAC Name
(3R,7Z,9R,10S,11E,13E,14aS,16aR,17R,18S,20aS,20bR)-9,17-dihydroxy-3,10,15,18,20b-pentamethyl-1-oxo-3,4,5,6,9,10,14a,16a,17,18,19,20,20a,20b-tetradecahydro-1H-naphtho[1,2-c]oxacyclohexadecine-8-carboxylic acid
Synonym Source
(+)-tubelactomicin A ChEBI
Registry Number Type Source
8741997 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
11132953 PubMed citation Europe PMC
11132954 PubMed citation Europe PMC
15901184 PubMed citation Europe PMC
15901185 PubMed citation Europe PMC
Last Modified
10 October 2012