CHEBI:66741 - PF 1163B

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ChEBI Name PF 1163B
ChEBI ID CHEBI:66741
Definition A macrolide antibiotic that is 4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione substituted by a 4-(2-hydroxyethoxy)benzyl group at position 3 and a pentyl group at position 13 (the 3S,10R,13S stereoisomer). It is isolated from Penicillium sp.PF1163 and exhibits antifungal activity against the pathogenic fungal strain Candida albicans TIMM1768.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C27H43NO5
Net Charge 0
Average Mass 461.63400
Monoisotopic Mass 461.31412
InChI InChI=1S/C27H43NO5/c1-4-5-6-10-24-15-12-21(2)9-7-8-11-26(30)28(3)25(27(31)33-24)20-22-13-16-23(17-14-22)32-19-18-29/h13-14,16-17,21,24-25,29H,4-12,15,18-20H2,1-3H3/t21-,24-,25+/m1/s1
InChIKey PCRJJAXIHTZHNU-SDUSCBPUSA-N
SMILES CCCCC[C@@H]1CC[C@H](C)CCCCC(=O)N(C)[C@@H](Cc2ccc(OCCO)cc2)C(=O)O1
Metabolite of Species Details
Penicillium (NCBI:txid5073) of strain PF1163 See: PubMed
Roles Classification
Biological Role(s): Penicillium metabolite
Any fungal metabolite produced during a metabolic reaction in Penicillium.
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
(via macrolide antibiotic )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing PF 1163B (CHEBI:66741) has role Penicillium metabolite (CHEBI:76964)
PF 1163B (CHEBI:66741) has role antifungal agent (CHEBI:35718)
PF 1163B (CHEBI:66741) is a aromatic ether (CHEBI:35618)
PF 1163B (CHEBI:66741) is a lactam (CHEBI:24995)
PF 1163B (CHEBI:66741) is a macrolide antibiotic (CHEBI:25105)
IUPAC Name
(3S,10R,13R)-3-[4-(2-hydroxyethoxy)benzyl]-4,10-dimethyl-13-pentyl-1-oxa-4-azacyclotridecane-2,5-dione
Synonym Source
(−)-PF 1163B ChEBI
Registry Number Type Source
8521076 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10695680 PubMed citation Europe PMC
10724005 PubMed citation Europe PMC
10724006 PubMed citation Europe PMC
14572246 PubMed citation Europe PMC
Last Modified
13 January 2014