idebenone (CHEBI:31687)

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ChEBI Name	idebenone

ChEBI ID	CHEBI:31687

Definition	A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C19H30O5

Net Charge

Average Mass

338.444

Monoisotopic Mass

338.20932

InChI

InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3

InChIKey

JGPMMRGNQUBGND-UHFFFAOYSA-N

SMILES

COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O

Roles Classification
Chemical Role(s):	antioxidant A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.

Biological Role(s):	ferroptosis inhibitor Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.

ChEBI Ontology
Outgoing	idebenone (CHEBI:31687) has role antioxidant (CHEBI:22586) idebenone (CHEBI:31687) has role ferroptosis inhibitor (CHEBI:173084) idebenone (CHEBI:31687) is a 1,4-benzoquinones (CHEBI:132124) idebenone (CHEBI:31687) is a primary alcohol (CHEBI:15734)

IUPAC Name

2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone

Synonyms	Sources
2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone	ChEBI
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone	ChemIDplus
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione	IUPAC
6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone	ChemIDplus
6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinone	ChEBI
CV 2619	ChemIDplus
CV-2619	DrugCentral

Brand Name	Source
Raxone	DrugBank

Last Modified

26 May 2021