tyrphostin AG 1478 (CHEBI:75404)

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ChEBI Name	tyrphostin AG 1478

ChEBI ID	CHEBI:75404

Definition	A member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formula

C16H14ClN3O2

Net Charge

Average Mass

315.760

Monoisotopic Mass

315.07745

InChI

InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)

InChIKey

GFNNBHLJANVSQV-UHFFFAOYSA-N

SMILES

COC1=C(OC)C=C2C(NC3=CC(Cl)=CC=C3)=NC=NC2=C1

Roles Classification
Biological Role(s):	epidermal growth factor receptor antagonist An antagonist at the epidermal growth factor receptor. antiviral agent A substance that destroys or inhibits replication of viruses.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.

ChEBI Ontology
Outgoing	tyrphostin AG 1478 (CHEBI:75404) has role antineoplastic agent (CHEBI:35610) tyrphostin AG 1478 (CHEBI:75404) has role antiviral agent (CHEBI:22587) tyrphostin AG 1478 (CHEBI:75404) has role epidermal growth factor receptor antagonist (CHEBI:74440) tyrphostin AG 1478 (CHEBI:75404) has role geroprotector (CHEBI:176497) tyrphostin AG 1478 (CHEBI:75404) is a aromatic ether (CHEBI:35618) tyrphostin AG 1478 (CHEBI:75404) is a monochlorobenzenes (CHEBI:83403) tyrphostin AG 1478 (CHEBI:75404) is a quinazolines (CHEBI:38530)

IUPAC Name

N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine

Last Modified

27 October 2021