tetramethylpyrazine (CHEBI:133246)

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ChEBI Name	tetramethylpyrazine

ChEBI ID	CHEBI:133246

Definition	A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Sabrina Toro

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Formula

C8H12N2

Net Charge

Average Mass

136.195

Monoisotopic Mass

136.10005

InChI

InChI=1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3

InChIKey

FINHMKGKINIASC-UHFFFAOYSA-N

SMILES

C=1(N=C(C(=NC1C)C)C)C

Metabolite of Species	Details
Ligusticum wallichii (IPNI: 844646-1)	See: PubMed
Corynebacterium glutamicum (NCBI:txid1718)	See: European Journal of Organic Chemistry, 2010 , 2687-2695
Ephedra sinica (NCBI:txid33152)	See: PubMed

Roles Classification
Biological Role(s):	apoptosis inhibitor Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms. bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. (via alkaloid )

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. vasodilator agent A drug used to cause dilation of the blood vessels. platelet aggregation inhibitor A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.

ChEBI Ontology
Outgoing	tetramethylpyrazine (CHEBI:133246) has role antineoplastic agent (CHEBI:35610) tetramethylpyrazine (CHEBI:133246) has role apoptosis inhibitor (CHEBI:68494) tetramethylpyrazine (CHEBI:133246) has role bacterial metabolite (CHEBI:76969) tetramethylpyrazine (CHEBI:133246) has role neuroprotective agent (CHEBI:63726) tetramethylpyrazine (CHEBI:133246) has role platelet aggregation inhibitor (CHEBI:50427) tetramethylpyrazine (CHEBI:133246) has role vasodilator agent (CHEBI:35620) tetramethylpyrazine (CHEBI:133246) is a alkaloid (CHEBI:22315) tetramethylpyrazine (CHEBI:133246) is a pyrazines (CHEBI:38314)

IUPAC Name

tetramethylpyrazine

Last Modified

02 October 2018