CHEBI:31905 - nicorandil

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ChEBI Name nicorandil ChEBI ID CHEBI:31905 Definition A pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris. Stars This entity has been manually annotated by the ChEBI Team. Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Read full article at Wikipedia Formula C8H9N3O4 Net Charge 0 Average Mass 211.17480 Monoisotopic Mass 211.05931 InChI InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12) InChIKey LBHIOVVIQHSOQN-UHFFFAOYSA-N SMILES [O-][N+](=O)OCCNC(=O)c1cccnc1 Roles Classification Biological Role(s): potassium channel opener A potassium channel modulator that opens the potassium channel. Application(s): vasodilator agent A drug used to cause dilation of the blood vessels. View more via ChEBI Ontology ChEBI Ontology Outgoing nicorandil (CHEBI:31905) has functional parent nicotinamide (CHEBI:17154) nicorandil (CHEBI:31905) has role potassium channel opener (CHEBI:79085) nicorandil (CHEBI:31905) has role vasodilator agent (CHEBI:35620) nicorandil (CHEBI:31905) is a nitrate ester (CHEBI:51080) nicorandil (CHEBI:31905) is a pyridinecarboxamide (CHEBI:25529) IUPAC Name 2-[(pyridin-3-ylcarbonyl)amino]ethyl nitrate INNs Sources nicorandil WHO MedNet nicorandil WHO MedNet nicorandil WHO MedNet nicorandilum WHO MedNet Synonyms Sources 2-nicotinamidoethyl nitrate ChemIDplus N-(2-hydroxyethyl)nicotinamide nitrate ChemIDplus SG 75 ChemIDplus SG-75 ChemIDplus Brand Names Sources Adancor ChEBI Ikorel ChEBI Perisalol ChEBI Sigmart ChEBI Manual Xrefs Databases 1919 DrugCentral C13280 KEGG COMPOUND D01810 KEGG DRUG DE2714713 Patent LSM-6009 LINCS Nicorandil Wikipedia US4200640 Patent View more database links Registry Numbers Types Sources 65141-46-0 CAS Registry Number KEGG COMPOUND 65141-46-0 CAS Registry Number ChemIDplus Citations Types Sources 23841868 PubMed citation Europe PMC 23845070 PubMed citation Europe PMC 24685703 PubMed citation Europe PMC 24837014 PubMed citation Europe PMC 24952900 PubMed citation Europe PMC 25319832 PubMed citation Europe PMC Last Modified 22 February 2017