CHEBI:28502 - tolazoline

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ChEBI Name tolazoline
ChEBI ID CHEBI:28502
Definition A member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:9614, CHEBI:27018
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Formula C10H12N2
Net Charge 0
Average Mass 160.21576
Monoisotopic Mass 160.10005
InChI InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)
InChIKey JIVZKJJQOZQXQB-UHFFFAOYSA-N
SMILES C1CN=C(Cc2ccccc2)N1
Roles Classification
Biological Role(s): alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Application(s): alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
vasodilator agent
A drug used to cause dilation of the blood vessels.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing tolazoline (CHEBI:28502) has role α-adrenergic antagonist (CHEBI:37890)
tolazoline (CHEBI:28502) has role antihypertensive agent (CHEBI:35674)
tolazoline (CHEBI:28502) has role vasodilator agent (CHEBI:35620)
tolazoline (CHEBI:28502) is a imidazoles (CHEBI:24780)
IUPAC Name
2-benzyl-4,5-dihydro-1H-imidazole
Synonyms Sources
2-Benzyl-2-imidazoline ChemIDplus
2-Benzyl-4,5-imidazoline ChemIDplus
2-Benzylimidazoline ChemIDplus
4,5-Dihydro-2-(phenylmethyl)-1H-imidazole KEGG COMPOUND
Tolazoline KEGG COMPOUND
Manual Xrefs Databases
2695 DrugCentral
C07147 KEGG COMPOUND
D08614 KEGG DRUG
DB00797 DrugBank
HMDB0014935 HMDB
LSM-3020 LINCS
Tolazoline Wikipedia
View more database links
Registry Numbers Types Sources
128757 Beilstein Registry Number Beilstein
128757 Reaxys Registry Number Reaxys
59-98-3 CAS Registry Number KEGG COMPOUND
59-98-3 CAS Registry Number NIST Chemistry WebBook
59-98-3 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
14366198 PubMed citation Europe PMC
23321455 PubMed citation Europe PMC
23438114 PubMed citation Europe PMC
Last Modified
22 February 2017