Services
Research
Training
Industry
About us
ChEBI
Examples:
iron*
,
InChI=1S/CH4O/c1-2/h2H,1H3
,
caffeine
Advanced
Home
Advanced Search
Browse
Documentation
Download
Tools
About ChEBI
Submit
Contact us
DiNA
Statistics
Entity of the Month
Periodic Table
Ontology
Train online
User Manual
Annotation Manual
Developer Manual
FAQ's
BiNChE
libChEBI
Web Services
ChEBI
> Main
CHEBI:63791 - lenalidomide
Main
ChEBI Ontology
Automatic Xrefs
Reactions
Pathways
Models
ChEBI Name
lenalidomide
ChEBI ID
CHEBI:63791
Definition
A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-α.
Stars
This entity has been manually annotated by the ChEBI Team.
Submitter
Anonymous
Supplier Information
Download
Molfile
XML
SDF
Find compounds which contain this structure
Find compounds which resemble this structure
Take structure to the Advanced Search
Wikipedia
License
Read full article at Wikipedia
Formula
C13H13N3O3
Net Charge
0
Average Mass
259.26060
Monoisotopic Mass
259.09569
InChI
InChI=1S/C13H13N3O3/c14-
9-
3-
1-
2-
7-
8(9)
6-
16(13(7)
19)
10-
4-
5-
11(17)
15-
12(10)
18/h1-
3,10H,4-
6,14H2,(H,15,17,18)
InChIKey
GOTYRUGSSMKFNF-UHFFFAOYSA-N
SMILES
Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O
Roles Classification
Chemical Role
(s):
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Br
o
nsted acid).
(via
organic amino compound
)
Biological Role
(s):
immunomodulator
Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
Application
(s):
angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
immunomodulator
Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
lenalidomide (
CHEBI:63791
)
has role
angiogenesis inhibitor (
CHEBI:48422
)
lenalidomide (
CHEBI:63791
)
has role
antineoplastic agent (
CHEBI:35610
)
lenalidomide (
CHEBI:63791
)
has role
immunomodulator (
CHEBI:50846
)
lenalidomide (
CHEBI:63791
)
is a
aromatic amine (
CHEBI:33860
)
lenalidomide (
CHEBI:63791
)
is a
dicarboximide (
CHEBI:35356
)
lenalidomide (
CHEBI:63791
)
is a
isoindoles (
CHEBI:24897
)
lenalidomide (
CHEBI:63791
)
is a
piperidones (
CHEBI:48589
)
IUPAC Name
3-(4-amino-1-oxo-1,3-dihydro-2
H
-isoindol-2-yl)piperidine-2,6-dione
INN
Source
lenalidomide
KEGG DRUG
Synonyms
Sources
1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
ChEBI
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
ChemIDplus
Brand Name
Source
Revlimid
KEGG DRUG
Manual Xrefs
Databases
3317
DrugCentral
D04687
KEGG DRUG
DB00480
DrugBank
Lenalidomide
Wikipedia
LSM-6187
LINCS
View more database links
Registry Numbers
Types
Sources
191732-72-6
CAS Registry Number
ChemIDplus
8335210
Reaxys Registry Number
Reaxys
Citations
Types
Sources
21533608
PubMed citation
Europe PMC
21823830
PubMed citation
Europe PMC
21835953
PubMed citation
Europe PMC
22001752
PubMed citation
Europe PMC
22066855
PubMed citation
Europe PMC
22107129
PubMed citation
Europe PMC
22143062
PubMed citation
Europe PMC
22211836
PubMed citation
Europe PMC
22241792
PubMed citation
Europe PMC
22245427
PubMed citation
Europe PMC
22245805
PubMed citation
Europe PMC
22245806
PubMed citation
Europe PMC
22246035
PubMed citation
Europe PMC
22253550
PubMed citation
Europe PMC
22261445
PubMed citation
Europe PMC
Last Modified
22 February 2017