parthenolide (CHEBI:7939)

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ChEBI Name	parthenolide

ChEBI ID	CHEBI:7939

Definition	A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C15H20O3

Net Charge

Average Mass

248.31750

Monoisotopic Mass

248.14124

InChI

InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1

InChIKey

KTEXNACQROZXEV-PVLRGYAZSA-N

SMILES

[H][C@@]12CC\C(C)=C\CC[C@@]3(C)O[C@]3([H])[C@@]1([H])OC(=O)C2=C

Roles Classification
Biological Role(s):	drug allergen Any drug which causes the onset of an allergic reaction. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. inhibitor A substance that diminishes the rate of a chemical reaction.

Application(s):	drug allergen Any drug which causes the onset of an allergic reaction. non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. peripheral nervous system drug A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system.

ChEBI Ontology
Outgoing	parthenolide (CHEBI:7939) has role drug allergen (CHEBI:88188) parthenolide (CHEBI:7939) has role inhibitor (CHEBI:35222) parthenolide (CHEBI:7939) has role non-narcotic analgesic (CHEBI:35481) parthenolide (CHEBI:7939) has role non-steroidal anti-inflammatory drug (CHEBI:35475) parthenolide (CHEBI:7939) has role peripheral nervous system drug (CHEBI:49110) parthenolide (CHEBI:7939) is a sesquiterpene lactone (CHEBI:37667)

Incoming	3β-hydroxyparthenolide (CHEBI:144561) has functional parent parthenolide (CHEBI:7939)

IUPAC Name

(1aR,4E,7aS,10aS,10bR)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one

Synonyms	Sources
(-)-Parthenolide	ChemIDplus
4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone	ChemIDplus
parthenolide	UniProt
Parthenolide	KEGG COMPOUND

Last Modified

18 August 2019