CHEBI:73032 - deracoxib

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ChEBI Name deracoxib
ChEBI ID CHEBI:73032
Definition A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3, and 5 by 4-sulfamoylphenyl, difluoromethyl and 3-fluoro-4-methoxyphenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C17H14F3N3O3S
Net Charge 0
Average Mass 397.37200
Monoisotopic Mass 397.07080
InChI InChI=1S/C17H14F3N3O3S/c1-26-16-7-2-10(8-13(16)18)15-9-14(17(19)20)22-23(15)11-3-5-12(6-4-11)27(21,24)25/h2-9,17H,1H3,(H2,21,24,25)
InChIKey WAZQAZKAZLXFMK-UHFFFAOYSA-N
SMILES COc1ccc(cc1F)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)F
Roles Classification
Biological Role(s): cyclooxygenase 2 inhibitor
A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
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ChEBI Ontology
Outgoing deracoxib (CHEBI:73032) has role cyclooxygenase 2 inhibitor (CHEBI:50629)
deracoxib (CHEBI:73032) has role non-narcotic analgesic (CHEBI:35481)
deracoxib (CHEBI:73032) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
deracoxib (CHEBI:73032) is a organofluorine compound (CHEBI:37143)
deracoxib (CHEBI:73032) is a pyrazoles (CHEBI:26410)
deracoxib (CHEBI:73032) is a sulfonamide (CHEBI:35358)
IUPAC Name
4-[3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl]benzenesulfonamide
INNs Sources
déracoxib WHO MedNet
deracoxib WHO MedNet
deracoxib WHO MedNet
deracoxibum WHO MedNet
Synonyms Sources
SC 046 ChemIDplus
SC 46 ChemIDplus
SC 59046 ChemIDplus
SC-59046 ChemIDplus
Brand Name Source
Deramaxx ChemIDplus
Manual Xrefs Databases
2971 VSDB
D03689 KEGG DRUG
Deracoxib Wikipedia
LSM-3536 LINCS
View more database links
Registry Numbers Types Sources
169590-41-4 CAS Registry Number ChemIDplus
169590-41-4 CAS Registry Number KEGG DRUG
7727810 Reaxys Registry Number Reaxys
Last Modified
25 February 2016