CHEBI:52724 - PS-519

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ChEBI Name PS-519
ChEBI ID CHEBI:52724
Definition A β-lactone proteasome inhibitor derived from lactacystin.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C12H19NO4
Net Charge 0
Average Mass 241.28360
Monoisotopic Mass 241.13141
InChI InChI=1S/C12H19NO4/c1-4-5-7-9-12(11(16)17-9,13-10(7)15)8(14)6(2)3/h6-9,14H,4-5H2,1-3H3,(H,13,15)/t7-,8+,9+,12-/m1/s1
InChIKey KMXHEXRPYSXLRN-JDVQERKKSA-N
SMILES CCC[C@@H]1[C@@H]2OC(=O)[C@@]2(NC1=O)[C@@H](O)C(C)C
Roles Classification
Application(s): proteasome inhibitor
A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
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ChEBI Ontology
Outgoing PS-519 (CHEBI:52724) has functional parent lactacystin (CHEBI:52722)
PS-519 (CHEBI:52724) has role proteasome inhibitor (CHEBI:52726)
PS-519 (CHEBI:52724) is a β-lactone (CHEBI:49043)
PS-519 (CHEBI:52724) is a lactam (CHEBI:24995)
IUPAC Name
(1R,4R,5S)-1-[(1S)-1-hydroxy-2-methylpropyl]-4-propyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
Registry Number Type Source
8492768 Beilstein Registry Number Beilstein
Last Modified
08 July 2009