gamma-mangostin (CHEBI:67548)

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ChEBI Name	γ-mangostin

ChEBI ID	CHEBI:67548

ChEBI ASCII Name	gamma-mangostin

Definition	A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C23H24O6

Net Charge

Average Mass

396.43310

Monoisotopic Mass

396.15729

InChI

InChI=1S/C23H24O6/c1-11(2)5-7-13-15(24)9-18-20(22(13)27)23(28)19-14(8-6-12(3)4)21(26)16(25)10-17(19)29-18/h5-6,9-10,24-27H,7-8H2,1-4H3

InChIKey

VEZXFTKZUMARDU-UHFFFAOYSA-N

SMILES

CC(C)=CCc1c(O)cc2oc3cc(O)c(O)c(CC=C(C)C)c3c(=O)c2c1O

Metabolite of Species	Details
Cratoxylum cochinchinense (NCBI:txid271749)	Found in stem (BTO:0001300). Methanolic extract of dried and ground stems See: PubMed

Roles Classification
Biological Role(s):	protein kinase inhibitor An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases. plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	γ-mangostin (CHEBI:67548) has role antineoplastic agent (CHEBI:35610) γ-mangostin (CHEBI:67548) has role plant metabolite (CHEBI:76924) γ-mangostin (CHEBI:67548) has role protein kinase inhibitor (CHEBI:37699) γ-mangostin (CHEBI:67548) is a phenols (CHEBI:33853) γ-mangostin (CHEBI:67548) is a xanthones (CHEBI:51149)

IUPAC Name

1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

Last Modified

09 January 2014