dipyridamole (CHEBI:4653)

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ChEBI Name	dipyridamole

ChEBI ID	CHEBI:4653

Definition	A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C24H40N8O4

Net Charge

Average Mass

504.62592

Monoisotopic Mass

504.31725

InChI

InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2

InChIKey

IZEKFCXSFNUWAM-UHFFFAOYSA-N

SMILES

OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	adenosine phosphodiesterase inhibitor EC 3.5.4.4 (adenosine deaminase) inhibitor An EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor that interferes with the action of adenosine deaminase (EC 3.5.4.4).

Application(s):	platelet aggregation inhibitor A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. vasodilator agent A drug used to cause dilation of the blood vessels.

ChEBI Ontology
Outgoing	dipyridamole (CHEBI:4653) has role adenosine phosphodiesterase inhibitor (CHEBI:50444) dipyridamole (CHEBI:4653) has role EC 3.5.4.4 (adenosine deaminase) inhibitor (CHEBI:50445) dipyridamole (CHEBI:4653) has role platelet aggregation inhibitor (CHEBI:50427) dipyridamole (CHEBI:4653) has role vasodilator agent (CHEBI:35620) dipyridamole (CHEBI:4653) is a piperidines (CHEBI:26151) dipyridamole (CHEBI:4653) is a pyrimidopyrimidine (CHEBI:48514) dipyridamole (CHEBI:4653) is a tertiary amino compound (CHEBI:50996) dipyridamole (CHEBI:4653) is a tetrol (CHEBI:33573)

IUPAC Name

2,2',2'',2'''-[(4,8-dipiperidin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol

Last Modified

22 February 2017