Mrv0541 02261409272D          

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 16 29  1  1  0  0  0
M  END
> <ID>
CHEBI:34848

> <NAME>
mevastatin

> <DEFINITION>
A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.

> <STAR>
3

> <SYNONYM>
ML-236B; ML 236 B; Mevastatin; mevastatin; CS 500; Compactin; antibiotic ML 236B

> <IUPAC_NAME>
(1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate

> <INN>
mevastatinum; mevastatine; mevastatina; mevastatin

> <FORMULA>
C23H34O5

> <MASS>
390.51310

> <MONOISOTOPIC_MASS>
390.24062

> <CHARGE>
0

> <SMILES>
CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

> <INCHI>
InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1

> <INCHIKEY>
AJLFOPYRIVGYMJ-INTXDZFKSA-N

> <CAS_REGISTRY_NUMBER>
73573-88-3

> <REAXYS_REGISTRY_NUMBER>
3630717

> <CHEMIDPLUS>
73573-88-3

> <DRUGBANK_ACCESSION>
DB06693

> <KEGG_COMPOUND_ACCESSION>
C13963

> <KNAPSACK_ACCESSION>
C00000564

> <LINCS_ACCESSION>
LSM-4123

> <WIKIPEDIA_ACCESSION>
Mevastatin

> <PUBMED_CITATION>
11283400; 12403272; 15274361; 15531285; 15786722; 18672387; 18936176; 20629200; 23918904; 24462564; 3170348; 3719857

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